96145-98-1

Basic information

• Product Name: 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol
• Synonyms: 5-Hydroxy-1-phenyl-3-trifluoromethylpyrazole;1-Phenyl-3-(trifluoromethyl)-1H-pyrazol-5-ol;5-Hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazole;2-Phenyl-5-trifluoro
• CAS NO: 96145-98-1
• Molecular Formula: C₁₀H₇F₃N₂O
• Molecular Weight: 228.17
• Product Categories: Heterocyclic Compounds
• Mol File: 96145-98-1.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 318.4 °C at 760mmHg
• Flash Point: 146.4 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol(96145-98-1)
• EPA Substance Registry System: 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol(96145-98-1)

Safety Data

• Hazardous Substances Data: 96145-98-1(Hazardous Substances Data)

Usage

Description

2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol is a chemical compound belonging to the pyrazol class, characterized by the presence of a trifluoromethyl group and a phenyl ring. It exhibits unique structural features and properties that make it a versatile molecule for various applications.

Uses

Used in Pharmaceutical Industry:
2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol is used as a key intermediate in the synthesis of 5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, which is an inhibitor of ADAMTS-5. This enzyme plays a crucial role in the degradation of extracellular matrix proteins, and its inhibition can be beneficial in treating various diseases, such as osteoarthritis and other inflammatory conditions.
Additionally, due to its unique structure and properties, 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol may also be employed as a building block for the development of other pharmaceutical compounds with potential therapeutic applications. Its versatility and reactivity make it a promising candidate for further research and drug discovery efforts.

InChI:InChI=1/C10H7F3N2O/c11-10(12,13)8-6-9(16)15(14-8)7-4-2-1-3-5-7/h1-6,16H

Upstream product

• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 1522-43-6 ethyl 3-oxo-4,4,4-trifluorobutanoate enol 
• 100-63-0 phenylhydrazine 
• 59-88-1 phenylhydrazine hydrochloride 
• 122431-24-7 (N-((2-chloro-3,5-di(trifluoromethyl)phenyl)amino)carbonyl)(2,6-difluorophenyl)formamide 
• 83643-84-9 methyl 4,4,4-trifluoroacetoacetate 

Downstream Products

• 159391-22-7 (S)-3-Benzyloxycarbonylamino-4-oxo-5-(2-phenyl-5-trifluoromethyl-2H-pyrazol-3-yloxy)-pentanoic acid tert-butyl ester 
• 914399-29-4 5-ethoxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazole 
• 318288-78-7 5‐chloro‐1‐phenyl‐3‐(trifluoromethyl)‐1H‐pyrazole‐4‐carbaldehyde 
• 946409-60-5 5-difluoromethoxy-4-hydroxymethyl-1-phenyl-3-trifluoromethylpyrazole 

Relevant articles and documents

In vitro metabolism of the new insecticide flupyrazofos by rat liver microsomes

1. The in vitro metabolism of the new insecticide flupyrazofos was studied using rat liver microsomes. Two metabolites were produced and identified as O,O-diethyl O-(1-phenyl-3-trifluoromethyl-5-pyrazoyl) phosphoric acid ester (flupyrazofos oxon) and 1-phenyl-3-trifluoromethyl-5-hydroxypyrazole (PTMHP) based on UV and mass spectral analysis. 2. Cytochrome P450 oxidatively converted flupyrazofos to flupyrazofos oxon, a major metabolite and phenobarbital-induced microsomes increased this desulphuration by 8-fold. 3. Flupyrazofos oxon was converted to PTMHP with a half-life of 47.8 min by chemical hydrolysis and this conversion also proceeded non-enzymatically under our microsomal incubation conditions.

F(1H-Pyrazol-4-yl)methylene-Hydrazide derivatives: Synthesis and antimicrobial activity

This paper investigates the seismic and collapse performance of shape memory alloy (SMA) braced steel frame structures considering the effects of various brace design parameters and ultimate state of SMAs. An SMA braced steel frame building is designed to

Regiocontrolled N-, O- and C-methylation of 1-phenyl-3-polyfluoroalkyl-1H-pyrazol-5-ols

The approaches for regiocontrolled N-, O- and C-methylation of 1-phenyl-3-polyfluoroalkyl-1H-pyrazol-5-ols have been developed. The chemoselective N-methylation proved to be an efficient method for the synthesis of polyfluorinated antipyrine analogs. In addition, we reinvestigated the structure of 3-polyfluoroalkyl-1-phenylpyrazol-5-ols by the X-Ray analysis. The quantum-chemical calculations were used for an explanation of methylation processes. The preliminary biological testing revealed a significant analgesic activity of trifluoromethyl-containing antipyrine.