96225-80-8

Basic information

• Product Name: 4-AMINO-6-MORPHOLINOPYRIMIDINE
• Synonyms: 4-AMINO-6-MORPHOLINOPYRIMIDINE;6-morpholino-pyrimidin-4-ylamine;6-MorpholinopyriMidin-4-aMine;6-(4-morpholinyl)-4-Pyrimidinamine;6-morpholin-4-ylpyrimidin-4-amine
• CAS NO: 96225-80-8
• Molecular Formula: C₈H₁₂N₄O
• Molecular Weight: 180.21
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 96225-80-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 420.896 °C at 760 mmHg
• Flash Point: 208.351 °C
• Appearance: /
• Density: 1.274 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-AMINO-6-MORPHOLINOPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-6-MORPHOLINOPYRIMIDINE(96225-80-8)
• EPA Substance Registry System: 4-AMINO-6-MORPHOLINOPYRIMIDINE(96225-80-8)

Safety Data

• Hazardous Substances Data: 96225-80-8(Hazardous Substances Data)

Usage

General Description

4-Amino-6-morpholinopyrimidine is a chemical compound with the molecular formula C7H10N4O. It is a pyrimidine derivative containing an amino group and a morpholinyl group. 4-AMINO-6-MORPHOLINOPYRIMIDINE is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used in organic synthesis as a building block for creating more complex molecules. Additionally, 4-amino-6-morpholinopyrimidine has potential applications in medicinal chemistry, particularly in the development of new drugs for the treatment of various diseases.

InChI:InChI=1/C8H12N4O/c9-7-5-8(11-6-10-7)12-1-3-13-4-2-12/h5-6H,1-4H2,(H2,9,10,11)

Upstream product

• 110-91-8 morpholine 
• 5305-59-9 4-amino-6-chloropyrimidine 

Relevant articles and documents

Design, synthesis and biological evaluation of pyridone–aminal derivatives as MNK1/2 inhibitors

Excessive phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) plays a major role in the dysregulation of mRNA translation and the activation of tumor cell signaling. eIF4E is exclusively phosphorylated by mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2) on Ser209. So, MNK1/2 inhibitors could decrease the level of p-eIF4E and regulate tumor-associated signaling pathways. A series of pyridone–aminal derivatives were synthesized and evaluated as MNK1/2 inhibitors. Several compounds exhibited great inhibitory activity against MNK1/2 and selected compounds showed moderate to excellent anti-proliferative potency against hematologic cancer cell lines. In particular, compound 42i (MNK1 IC50 = 7.0 nM; MNK2 IC50 = 6.1 nM) proved to be the most potent compound against TMD-8 cell line with IC50 value of 0.91 μM. Furthermore, 42i could block the phosphorylation level of eIF4E in CT-26 cell line, and 42i inhibited the tumor growth of CT-26 allograft model significantly. These results indicated that compound 42i was a promising MNK1/2 inhibitor for the potent treatment of colon cancer.

Substituted pyrimidine compounds and application thereof

The invention relates to substituted pyrimidine compounds and an application thereof. The substituted pyrimidine compounds are compounds shown in a formula I (the specific structure is shown in the specification or claims), stereoisomers of the compounds or pharmaceutically acceptable salts of the compounds. An in-vitro activity test proves that the substituted pyrimidine compounds have cholinesterase inhibiting activity, metal ion chelation, inhibition of generation of metal ion induced free radicals, inhibition of metal ion induced Abeta aggregation and the like. Therefore, the substituted pyrimidine compounds are expected to be used for preparing Alzheimer's disease treating and/or preventing drugs.