96372-83-7

Basic information

• Product Name: Piperidine, 1-[1,1'-biphenyl]-4-yl-
• CAS NO: 96372-83-7
• Molecular Formula: C17H19N
• Molecular Weight: 237.345
• Mol File: 96372-83-7.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-[1,1'-biphenyl]-4-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-[1,1'-biphenyl]-4-yl-(96372-83-7)
• EPA Substance Registry System: Piperidine, 1-[1,1'-biphenyl]-4-yl-(96372-83-7)

Safety Data

• Hazardous Substances Data: 96372-83-7(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 92-69-3 4-Phenylphenol 
• 2359-60-6 4-(1-piperidino)aniline 
• 100-58-3 phenylmagnesium bromide 
• 2051-62-9 4'-biphenyl chloride 
• 111-24-0 1,5-dibromo-pentane 
• 92-67-1 4-phenylalanine 
• 2156-71-0 N-chloropiperidine 
• 92-52-4 biphenyl 
• 4801-58-5 N-hydroxypiperidine 
• 613-37-6 4-methoxylbiphenyl 
• 144432-80-4 2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 5122-94-1 4-biphenylboronic acid 

Downstream Products

• 144432-80-4 2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 92-69-3 4-Phenylphenol 

Relevant articles and documents

Catalytic Amination of Phenols with Amines

Given the wide prevalence and ready availability of both phenols and amines, aniline synthesis through direct coupling between these starting materials would be extremely attractive. Herein, we describe a rhodium-catalyzed amination of phenols, which provides concise access to diverse anilines, with water as the sole byproduct. The arenophilic rhodium catalyst facilitates the inherently difficult keto–enol tautomerization of phenols by means of π-coordination, allowing for the subsequent dehydrative condensation with amines. We demonstrate the generality of this redox-neutral catalysis by carrying out reactions of a large array of phenols with various electronic properties and a wide variety of primary and secondary amines. Several examples of late-stage functionalization of structurally complex bioactive molecules, including pharmaceuticals, further illustrate the potential broad utility of the method.

Photoinduced Deaminative Borylation of Unreactive Aromatic Amines Enhanced by CO2

Herein, direct unreactive C-N borylation of aromatic amines by a photocatalyst was achieved. The C-N borylation of aromatic amines with bis(pinacolato)diboron (B2pin2) proceeded using a pyrene catalyst under light irradiation to afford desired borylated products and aminoborane as a byproduct. The yield of the borylated product improved under a CO2 atmosphere which probably reduced the inhibitory effect of aminoborane. Mechanistic studies suggested that the C-N bond cleavage and C-B bond formation proceeded via a concerted pathway.

Leaving Group Ability in Nucleophilic Aromatic Amination by Sodium Hydride-Lithium Iodide Composite

The methoxy group is generally considered as a poor leaving group for nucleophilic substitution reactions. This work verified the superior ability of the methoxy group in nucleophilic amination of arenes mediated by the sodium hydride and lithium iodide through experimental and computational approaches.