964-65-8

Basic information

• Product Name: Piperazine, 1-(3,4,5-trimethoxybenzoyl)-
• CAS NO: 964-65-8
• Molecular Formula: C14H20N2O4
• Molecular Weight: 280.324
• Mol File: 964-65-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(3,4,5-trimethoxybenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(3,4,5-trimethoxybenzoyl)-(964-65-8)
• EPA Substance Registry System: Piperazine, 1-(3,4,5-trimethoxybenzoyl)-(964-65-8)

Safety Data

• Hazardous Substances Data: 964-65-8(Hazardous Substances Data)

Upstream product

• 1246890-23-2 tert-butyl 4-(3,4,5-trimethoxybenzoyl)-1-piperazinecarboxylate 
• 110-85-0 piperazine 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 

Downstream Products

• 123947-21-7 1-(7-methoxy-2,3-dihydro-1-benzoxepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 1226909-06-3 (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one 
• 892495-21-5 2-[4-(3,4,5-trimethoxybenzoyl)-1-piperazinomethyl]-3,5,6-trimethylpyrazine 
• 667936-06-3 6,6-bis-(4-fluoro-phenyl)-1-[4-(3,4,5,-trimethoxy-benzoyl)-piperazin-1-yl]-hex-5-en-1-one 
• 119049-32-0 1-(3,4,5-trimethoxy-thiobenzoyl)-piperazine 
• 123947-63-7 1-(8-methoxy-2,3-dihydro-1-benzoxepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 151664-47-0 1-[(E)-3-Phenyl-3-(pyridin-4-yl)acryloyl]-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 133261-84-4 1-(3,3-Diphenylacryloyl)-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 123947-19-3 1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 123947-65-9 1-(7,8-dimethoxy-2,3-dihydro-1-benzoxepin-4-carbonyl)-4-(3, 4,5-trimethoxybenzoyl)piperazine 
• 98374-71-1 8-Chlor-5,10-dihydro-5-<<4-(3,4,5-trimethoxybenzoy)-1-piperazinyl>acetyl>-11H-dibenzo<1,4>diazepin-11-on 

Relevant articles and documents

Substituted benzoyl piperazine compound and application thereof in preparation of anti-chikungunya virus drug

The invention discloses an application of a substituted benzoyl piperazine compound in preparation of an anti-chikungunya virus drug. The substituted benzoyl piperazine compound has a structural general formula shown in the description, wherein R1, R2, R3

Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents

A series of new cinnamido-pyrrolo[2,1-c][1,4]benzodiazepine conjugates (4a-d and 5a-d) and their dimers (6a-d) have been designed, synthesized and evaluated for their biological activity. The anticancer screening of compound 4a by the NCI exhibited signif

(Pyridylcyanomethyl)piperazines as orally active PAF antagonists

A series of (pyridylcyanomethyl)piperazines was prepared and evaluated for PAF-antagonist activity. Compounds were tested in vitro in a PAF-induced platelet aggregation assay and in vivo in a PAF-induced hypotension test in normotensive rats. Oral activity was ascertained through a PAF-induced mortality test in mice. The main structure-activity trends of the series were established. Activity was mainly found in four skeletons: 1-acyl-4-(3- pyridylcyanomethyl)-piperazine, 1-acyl-4-(4-pyridylcyanomethyl)piperazine, 1- acyl-4-(3-pyridylcyanomethyl)piperidine, and 1-acyl-4-cyano-4-(3- pyridylamino)piperidine. The acyl substituents, diphenylacetyl and 3,3- diphenylpropionyl, provided the most active compounds, and the introduction of an amine or hydroxy group in the 3,3-diphenylpropionyl substituent led to further improvement in oral activity. As a result, three of the most active compounds (100, 114, and 115) have been selected for further pharmacological development.