96516-32-4

Basic information

• Product Name: (2-chloro-3-fluorophenyl)Methanol
• Synonyms: (2-chloro-3-fluorophenyl)Methanol;BenzeneMethanol, 2-chloro-3-fluoro-;2-Chloro-3-fluorobenzenemethanol;(2-Chloro-3-fluorophenyl)
• CAS NO: 96516-32-4
• Molecular Formula: C₇H₆ClFO
• Molecular Weight: 160.5733432
• Mol File: 96516-32-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-chloro-3-fluorophenyl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-3-fluorophenyl)Methanol(96516-32-4)
• EPA Substance Registry System: (2-chloro-3-fluorophenyl)Methanol(96516-32-4)

Safety Data

• Hazardous Substances Data: 96516-32-4(Hazardous Substances Data)

Usage

General Description

(2-chloro-3-fluorophenyl)Methanol is a chemical compound with the molecular formula C7H6ClFO. It is an organic compound that consists of a benzene ring with a hydroxyl group and chlorine and fluorine atoms attached. (2-chloro-3-fluorophenyl)Methanol is used in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It can also be used as an intermediate in the production of dyes and other organic compounds. (2-chloro-3-fluorophenyl)Methanol has potential applications in the field of medicinal chemistry due to its structural features, and it is being studied for its potential biological activities and pharmacological effects.

Upstream product

• 102940-86-3 3-chloro-3-fluorobenzoic acid 

Downstream Products

• 874285-19-5 1-(bromomethyl)-2-chloro-3-fluorobenzene 
• 96516-31-3 2-chloro-3-fluoro-benzaldehyde 
• 1292850-11-3 [5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2-chloro-3-fluorophenyl)methanol 
• 1292850-10-2 N-{4-chloro-2-[(2-chloro-3-fluorophenyl)hydroxymethyl]-phenyl}-2,2-dimethylpropionamide 

Relevant articles and documents

Discovery of Highly Potent Liver X Receptor β Agonists

Introducing a uniquely substituted phenyl sulfone into a series of biphenyl imidazole liver X receptor (LXR) agonists afforded a dramatic potency improvement for induction of ATP binding cassette transporters, ABCA1 and ABCG1, in human whole blood. The ag

Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors

Human immunodeficiency virus type 1 (HIV-1) integrase is a crucial target for antiretroviral drugs, and several keto - enol acid class (often referred to as diketo acid class) inhibitors have clinically exhibited-marked antiretroviral activity. Here, we show the synthesis and the detailed structure - activity relationship of the quinolone carboxylic acids as a novel monoketo acid class of integrase inhibitors. 6-(3-Chloro-2-fluorobenzyl)-1-((2S)-1-hydroxy-3,3- dimethylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 51, which showed an IC50 of 5.8 nMin the strand transfer assay and an ED50 of 0.6 nMin the antiviral assay, and 6-(3-chloro-2-fluorobenzyl) -1-((2S)-1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3- carboxylic acid 49, which had an IC50 of 7.2 nMand an ED50 of 0.9 nM, were the most potent compounds in this class. The monoketo acid 49 was much more potent at inhibiting integrasecatalyzed strand transfer processes than 3′-processing reactions, as is the case with the keto - enol acids. Elvitegravir 49 was chosen as a candidate for further studies and is currently in phase 3 clinical trials.