96574-01-5

Basic information

• Product Name: Salvianolic acid
• Synonyms: (2R)-3-(3,4-Dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid;SALVIANOLIC ACID A 98.0% BY HPLC;Danphenolic acid A;(R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)o;Salvianolic acid A, froM Salvia Miltiorrhiza;(R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)oxy)propanoic acid;(αR)-α-[[(2E)-3-[2-[(1E)-2-(3,4-Dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid;Dan phenolic acid A hydrate
• CAS NO: 96574-01-5
• Molecular Formula: C26H22O10
• Molecular Weight: 494.45
• Product Categories: Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 96574-01-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 164-167°C
• Boiling Point: 858.7 °C at 760 mmHg
• Flash Point: 292.9 °C
• Appearance: yellow/
• Density: 1.58 g/cm³
• Vapor Pressure: 2.04E-31mmHg at 25°C
• Refractive Index: 1.789
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: H2O: ≥19mg/mL
• PKA: 2.78±0.10(Predicted)
• BRN: 2660108
• CAS DataBase Reference: Salvianolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Salvianolic acid(96574-01-5)
• EPA Substance Registry System: Salvianolic acid(96574-01-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 96574-01-5(Hazardous Substances Data)

Usage

Description

Salvianolic acid is an antioxidant and free radical scavenging compound extracted from S. miltiorrhiza that has been investigated for its cardioprotective and chemopreventative properties. It has been reported to reduce leukocyte-endothelial adherence, as well as inhibit inflammation and matrix metalloproteinases, suppress apoptosis, and reduce lipid peroxidation in damaged cardiac tissue.

Uses

Used in Pharmaceutical Industry:
Salvianolic acid is used as a cardioprotective and chemopreventative agent for its ability to reduce leukocyte-endothelial adherence, inhibit inflammation and matrix metalloproteinases, suppress apoptosis, and reduce lipid peroxidation in damaged cardiac tissue.
Used in Antioxidant Applications:
Salvianolic acid A (Sal A) and salvianolic acid B (Sal B) are used as antioxidants for their high total antioxidant activities, with EC50 values of 1.35 ± 0.00 and 1.43 ± 0.01 μg/mL, respectively.

Biochem/physiol Actions

Salvianolic acid A is cell protective antioxidant originally isolated from Salvia. It has been found to attenuate PDGF-induced ROS formation in hepatic stellate cells and protected against isoproterenol-induced myocardial damage in rats.

InChI:InChI=1/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+