96754-91-5

Basic information

• Product Name: 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-7-hydroxy-4H-chromen-4-one
• Synonyms: 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-7-hydroxy-4H-chromen-4-one
• CAS NO: 96754-91-5
• Molecular Formula: C₁₇H₁₂O₅
• Molecular Weight: 296.27418
• Mol File: 96754-91-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-7-hydroxy-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-7-hydroxy-4H-chromen-4-one(96754-91-5)
• EPA Substance Registry System: 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-7-hydroxy-4H-chromen-4-one(96754-91-5)

Safety Data

• Hazardous Substances Data: 96754-91-5(Hazardous Substances Data)

Upstream product

• 121060-00-2 2,4-dihydroxyphenyl 3,4-ethylenedioxybenzyl ketone 
• 68-12-2 N,N-dimethyl-formamide 
• 122-51-0 orthoformic acid triethyl ester 
• 1125670-95-2 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-(tetrahydropyran-2-yloxy)isoflavone 
• 108-46-3 recorcinol 
• 17253-10-0 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetonitrile 
• 96754-87-9 7-Benzyloxy-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-chromen-4-one 

Downstream Products

• 637751-93-0 3-(2,3-dihydrobenzo[1,4]dioxan-6-yl)-7-hydroxy-8-(3-methylpiperidin-1-ylmethyl)-chromen-4-one 
• 637751-97-4 3-(2,3-dihydrobenzo[1,4]dioxan-6-yl)-7-hydroxy-8-(4-methylpiperidin-1-ylmethyl)-chromen-4-one 

Relevant articles and documents

7-Hydroxy-benzopyran-4-one derivatives: A novel pharmacophore of peroxisome proliferator-activated receptor α and -γ (PPARα and γ) dual agonists

Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARα and γ agonists discovered through a structure-driven design paradigm are described. The 7-hydroxy-benzopyran-4-one moiety (includes flavones, flavanones, and isoflavones) is the key pharmacophore of these novel molecules, exhibiting similarity to the core structure of both fibrates and thiazolidinediones. New lead PPAR ligands were identified from "natraceuticals" and synthetic analogues. In total, 77 molecules, including chalcones, flavones, flavanones, isoflavones, and pyrazole derivatives, were screened and structure-activity relationship studies of the dual agonists undertaken. Compounds 68, 70, 72, and 76 were identified as novel and potent dual PPARα and γ agonists. These novel molecules may have the potential to be the future leads in PPAR-related disorders, including type II diabetes mellitus and metabolic syndrome. 2009 American Chemical Society.

SYNTHETIC AND MODIFIED ISOFLAVONOIDS. III. SYNTHESIS OF BENZODIOXANE ANALOGUES OF PSEUDOBAPTIGENIN

Benzodioxane analogues of pseudobaptigenin with alkyl fragments in positions 2 and 6 of the chromone ring have been synthesized from α-(1,4-benzodioxan-6-yl)-2-hydroxy-6-alkylacetophenones.

Synthesis of hypolipidemic silybin analog 3',4'-ethylenedioxyflavonoids

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