969-33-5 Usage
Description
Cyproheptadine hydrochloride is an antihistamine drug with demonstrated antiserotonin activity both in vivo and in vitro. It exhibits anticholinergic and sedative effects and is considered more effective than other H1 blockers in managing cold urticaria.
Uses
Used in Pharmaceutical Industry:
Cyproheptadine hydrochloride is used as an antipruritic agent for the relief of itching caused by various conditions such as allergies, skin irritation, and insect bites.
Used in Pharmaceutical Industry:
Cyproheptadine hydrochloride is used as a 5-HT antagonist to block the action of serotonin, a neurotransmitter involved in various physiological processes, including mood regulation, appetite, and sleep.
Used in Pharmaceutical Industry:
Cyproheptadine hydrochloride is used as an antihistamine with antiserotonin properties for the treatment of cold urticaria, a type of hives triggered by exposure to cold temperatures. Its effectiveness in this application is attributed to its ability to block histamine release and its anticholinergic and sedative effects.
Biological Activity
Non-selective 5HT 2 antagonist, migraine prophylactic.
Clinical Use
#N/A
Safety Profile
Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: jaundice, liver function tests impaired, gastrointestinal effects. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. Whenheated
Metabolism
Undergoes almost complete metabolism in the liver.
The main metabolite found in humans is a quaternary
ammonium glucuronide conjugate of cyproheptadine.
40% is excreted in the urine mainly as metabolites and
2-20% via the faeces.
references
[1] levine b, green-johnson d, hogan s, smialek je. a cyproheptadine fatality. j anal toxicol. 1998 jan-feb;22(1):72-4.[2] lin oa, karim za, vemana hp, espinosa ev, khasawneh ft. the antidepressant 5-ht2a receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. plos one. 2014 jan 23;9(1):e87026.
Check Digit Verification of cas no
The CAS Registry Mumber 969-33-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,6 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 969-33:
(5*9)+(4*6)+(3*9)+(2*3)+(1*3)=105
105 % 10 = 5
So 969-33-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H21N.ClH/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;/h2-11H,12-15H2,1H3;1H
969-33-5Relevant articles and documents
Preparation method of cyproheptadine hydrochloride
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Paragraph 0049; 0054; 0056; 0061; 0063; 0068; 0070; 0075, (2019/11/14)
The invention discloses a preparation method of cyproheptadine hydrochloride. According to the invention, the existing preparation method of the cyproheptadine hydrochloride is integrally improved, sothat the whole synthesis step is greatly simplified; and the prepared cyproheptadine hydrochloride has higher purity and yield, and the preparation method reduces the use of organic solvents and hazardous chemicals, simplifies the operation steps, reduces the operation difficulty, not only reduces the cost but also lightens the environmental burden, and is more beneficial to large-scale industrial production.
