96988-65-7

Basic information

• Product Name: 2H-1,4-Benzoxazine, 3,4-dihydro-4-(phenylmethyl)-
• CAS NO: 96988-65-7
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Mol File: 96988-65-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2H-1,4-Benzoxazine, 3,4-dihydro-4-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Benzoxazine, 3,4-dihydro-4-(phenylmethyl)-(96988-65-7)
• EPA Substance Registry System: 2H-1,4-Benzoxazine, 3,4-dihydro-4-(phenylmethyl)-(96988-65-7)

Safety Data

• Hazardous Substances Data: 96988-65-7(Hazardous Substances Data)

Upstream product

• 46425-95-0 o-(benzylamino)phenol 
• 95-55-6 2-amino-phenol 
• 55247-36-4 Benzyl-[2-(2-chloro-phenoxy)-ethyl]-amine 
• 19202-00-7 (2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)(phenyl)methanone 

Downstream Products

• 96988-67-9 6-acetoxy-4-benzyl-3,4-dihydro-2H-1,4-benzoxazine 
• 96988-66-8 4-benzyl-3,4-dihydro-2H-1,4-benzoxazine N-oxide 

Relevant articles and documents

Vinyl selenones: Annulation agents for the synthesis of six-membered benzo-1,4-heterocyclic compounds

A novel and general approach to six-membered bicyclic benzo fused 1,4-heterocycles is described. The addition-cyclization cascade of benzo 1,2-diols, 1,2-thiols and 2-(benzylamino)phenols with stable and easily available vinyl selenones affords differently substituted 2,3-dihydro-1,4- benzodioxines, benzodithiines and 3,4-dihydro-2H-1,4-benzoxazines in good yields. The same procedure has been extended to the synthesis of 1,2,3,4-tetrahydroquinoxalines. All of these heterocycles are present in a variety of biologically active compounds.

Efficient nickel-mediated intramolecular amination of aryl chlorides

(Matrix presented) The use of an in situ generated Ni(0) catalyst associated with 2,2′-bipyridine or N,N′ -bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (SIPr) as a ligand and NaO-t-Bu as the base for the intramolecular coupling of aryl chlorides with amines is described. The procedure has been applied to the formation of five-, six-, and seven-membered rings.