97-15-4Relevant articles and documents
Quinoline derivative as well as preparation method and purpose thereof
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Paragraph 0307-0310, (2019/02/21)
The invention provides a quinoline derivative and a composition containing the derivative. The invention also provides a method for preparing the derivative and a purpose of the derivative for preventing or treating harmful pathogenic bacteria and killing
Design, synthesis and biological evaluation of sulfonamide-substituted diphenylpyrimidine derivatives (Sul-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with antitumor activity
Qu, Menghua,Liu, Zhihao,Zhao, Dan,Wang, Changyuan,Zhang, Jianbin,Tang, Zeyao,Liu, Kexin,Shu, Xiaohong,Yuan, Hong,Ma, Xiaodong
, p. 3989 - 3996 (2017/07/05)
A class of sulfonamide-substituted diphenylpyrimidines (Sul-DPPYs) were synthesized to improve activity against the focal adhesion kinase (FAK). Most of these new Sul-DPPYs displayed moderate activity against the FAK enzyme with IC50 values of less than 100?nM; regardless, they could effectively inhibit several classes of refractory cancer cell lines with IC50 values of less than 10?μM, including the pancreatic cancer cell lines (AsPC-1, Panc-1 and BxPC-3), the NSCLC-resistant H1975 cell line, and the B lymphocyte cell line (Ramos cells). Results of flow cytometry indicated that inhibitor 7e promoted apoptosis of pancreatic cancer cells in a dose-dependent manner. In addition, it almost completely induced the apoptosis at a concentration of 10?μM. Compound 7e may be selected as a potent FAK inhibitor for the treatment of pancreatic cancer.
REACTION OF N-ARYLSULFONAMIDES WITH NITROSATING AGENTS
Zakatov, V. V.,Dubina, V. L.,Gladshtein, I. Ya.
, p. 540 - 542 (2007/10/02)
Only the mononitro derivatives are formed by the action of nitrosating agents on N-arylsulfonamides containing halogen atom and alkoxy and alkyl groups in the amide ring.The nature of the effect and the directing action of the substituents are discussed a