97006-56-9Relevant articles and documents
A 3-aminomethyl -3, 5, 5-trimethyl method for preparing cyclohexylamine
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Paragraph 0017; 0068-0071, (2017/03/17)
The invention discloses a method for preparing 3-aminomethyl-3,5,5-trimethyl cyclohexylamine (IPDA). The method comprises the following steps: (a), reacting isophorone and halogenated isobutenyl magnesium to obtain 3-(2-methylpropenyl)-3,5,5-trimethyl cyclohexanone (IPA); (b), carrying out zonization reaction on the IPA and ozone to obtain 3-formyl-3,5,5-trimethyl-ring cyclohexanone (IPFM); (c) carrying out imidization reaction on the IPFM and ammonia to obtain 3-aminomethyl-3,5,5-trimethylcyclohexylimide (IPMI); and (d) carrying out catalytic hydrogenation reaction on the IPMI to obtain the IPDA. The method has the advantages that no HCN and hydrazine hydrate are used, no 3-amino-3,5,5-trimethyl-cyclohexanol (IPAA) which is difficult to separate is generated, the device cost is low, the reaction conditions are mild, the process chain is relatively complete and the yield of products are relatively high.
REACTION OF METHYL-SUBSTITUTED 7-CHLORO- AND 7,7-DICHLOROBICYCLOheptan-2-ones WITH SODIUM METHOXIDE AND THIOPHENOLATE
Kulinkovich, O. G.,Tishchenko, I. G.,Romashin, Yu. N.
, p. 81 - 85 (2007/10/02)
The reaction of exo-7-chloro-6-methylbicycloheptan-2-one, exo-7-chloro-4,4,6-trimethylbicycloheptan-2-one, 7,7-dichloro-6-methylbicyclo-heptan-2-one, and 7,7-dichloro-4,4,6-trimethylbicycloheptan-2-one with sodium methoxide takes place with opening of the cyclopropane ring and the formation of the corresponding 3-dimethoxymethyl- and 3-trimethoxymethylcyclohexanones.The reaction with sodium thiophenolate leads to the product from substitution of the exo-chlorine atom by the phenylthio group with retention of the three-membered ring.