97075-46-2

Basic information

• Product Name: 1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride
• Synonyms: 1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride
• CAS NO: 97075-46-2
• Molecular Formula: C28H30Cl2N2
• Molecular Weight: 465.4572
• Mol File: 97075-46-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: ?20°C
• Solubility: <46.55mg/ml in DMSO;insoluble in H2O
• CAS DataBase Reference: 1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride(97075-46-2)
• EPA Substance Registry System: 1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride(97075-46-2)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-50
• Safety Statements: 61
• Hazardous Substances Data: 97075-46-2(Hazardous Substances Data)

Usage

Description

1,2-Ethanediamine, N,N'-bis(diphenylmethyl)-, dihydrochloride is a chemical compound with the molecular formula C16H20Cl2N2. It is a white crystalline solid that is soluble in water and ethanol. 1,2-Ethanediamine, N,N'-bis(diphenylmethyl)-, dihydrochloride is also known as AMN082 and is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7). It has a molecular weight of 315.25 g/mol and a melting point of 230-232°C.

Uses

Used in Pharmaceutical Industry:
1,2-Ethanediamine, N,N'-bis(diphenylmethyl)-, dihydrochloride is used as a drug candidate for the treatment of neurological disorders. It acts as an agonist of mGluR7, a G-protein coupled receptor that modulates neurotransmission and synaptic plasticity. By activating mGluR7, AMN082 can potentially improve cognitive function and alleviate symptoms associated with neurological disorders such as Parkinson's disease and schizophrenia.
Used in Research Applications:
1,2-Ethanediamine, N,N'-bis(diphenylmethyl)-, dihydrochloride is used as a research tool to study the role of mGluR7 in various physiological and pathological processes. It can be used to investigate the mechanisms underlying the regulation of synaptic transmission, neuronal excitability, and plasticity. Additionally, it can be employed to explore the therapeutic potential of mGluR7 agonists in preclinical models of neurological disorders.
Used in Drug Discovery and Development:
1,2-Ethanediamine, N,N'-bis(diphenylmethyl)-, dihydrochloride is used as a lead compound in the development of novel therapeutic agents targeting mGluR7. Researchers can use this compound as a starting point to design and synthesize new molecules with improved pharmacological properties, such as increased selectivity, potency, and bioavailability. These new compounds can then be evaluated for their potential use in the treatment of neurological disorders and other conditions.

in vivo

treatment with amn082 was shown to penetrate into the brain and hence it modulated the level of stress hormones (acth and cortisol) in wild type animal. but these effects were not found in the mglur7 ko mouse [2].

references

[1]. pelkey ka, yuan x, lavezzari g, et al. mglur7 undergoes rapid internalization in response to activation by the allosteric agonist amn082. neuropharmacology, 2007, 52(1): 108-117.[2]. gasparini f, spooren w. allosteric modulators for mglu receptors. current neuropharmacology, 2007, 5(3): 187-194.