97165-23-6Relevant articles and documents
Biologically active sesquiterpenoid metabolites from the fungus Botrytis cinerea
Collado, Isidro G.,Hernandez-Galan, Rosario,Prieto, Victoria,Hanson, James R.,Rebordinos, Laureana G.
, p. 513 - 517 (1996)
Five new sesquiterpenoid metabolites, botryendial, botryenalol, 10-epi-dihydrobotrydial, methyl acetyl botryenaloate and 10-dehydroxy dihydrobotrydialone, have been isolated from Botrytis cinerea. The structures were elucidated by extensive NMR studies of the natural products and their derivatives. Copyright
Chemical transformations on botryane skeleton. Effect on the cytotoxic activity
Reino, Jose L.,Duran-Patron, Rosa,Segura, Inmaculada,Hernandez-Galan, Rosario,Riese, Hans H.,Collado, Isidro G.
, p. 344 - 349 (2007/10/03)
Eighteen compounds with a botryane skeleton have been obtained through chemical transformations of various toxins from the fungus Botrytis cinerea. During the course of these transformations, the C-10 carbon of the botryane skeleton was found to exhibit an interesting high regioselectivity to oxidizing and reducing agents. In addition, the cytotoxicity of 27 botryane derivatives was determined in vitro against Hs578T, MDA-MB-231, HT-1080, U87-MG, IMR-90, and HUVEC cell lines. The results of this study confirm that the cytotoxicity of botrydial (1) and its derivatives is related to the presence of a 1,5-dialdehyde functionality.