97188-27-7

Basic information

• Product Name: 3-isopropyl-1-(phenylsulfonyl)pyrrole
• CAS NO: 97188-27-7
• Molecular Weight: 249.334
• Mol File: 97188-27-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-isopropyl-1-(phenylsulfonyl)pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-isopropyl-1-(phenylsulfonyl)pyrrole(97188-27-7)
• EPA Substance Registry System: 3-isopropyl-1-(phenylsulfonyl)pyrrole(97188-27-7)

Safety Data

• Hazardous Substances Data: 97188-27-7(Hazardous Substances Data)

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 16851-82-4 N-phenylsulfonylpyrrole 
• 75-29-6 isopropyl chloride 

Downstream Products

• 199990-18-6 4-[3-(3-{[Bis-(4-isobutyl-phenyl)-methyl]-amino}-benzoyl)-4-isopropyl-pyrrol-1-yl]-butyric acid ethyl ester 
• 199989-71-4 4-[3-Isopropyl-4-(3-nitro-benzoyl)-pyrrol-1-yl]-butyric acid ethyl ester 
• 199989-72-5 4-[3-(3-Amino-benzoyl)-4-isopropyl-pyrrol-1-yl]-butyric acid ethyl ester 
• 199989-70-3 (4-Isopropyl-1H-pyrrol-3-yl)-(3-nitro-phenyl)-methanone 
• 97188-39-1 5-acetyl-3-isopropyl-1-(phenylsulfonyl)pyrrole 
• 97188-40-4 4-acetyl-3-isopropyl-1-(phenylsulfonyl)pyrrole 
• 97188-38-0 2-acetyl-3-isopropyl-1-(phenylsulfonyl)pyrrole 

Relevant articles and documents

Pyrrole chemistry. XXVIII. Substitution reactions of 1-(phenylsulfonyl)pyrrole and some derivatives

The preparative value of the 1-(phenylsulfonyl) N-blocking and directing group for the synthesis of 3-acylpyrroles has been further evaluated.Acetylation and benzoylation are strongly regiospecific and give good yields.However, the regiospecificity is not general and other substitution reactions give mixtures of 2- and 3-substitution or even mostly 2-substitution.Friedel and Crafts tert-butylation gives 3-tert-butyl-1-(phenylsulfonyl)pyrrole and provides a useful route to tert-butylpyrrole, but ethylation and isopropylation give mixtures.Acylations of 2- and 3-alkyl-1-(phenylsulfonyl)pyrroles show little evidence of useful regiospecificity.