97267-35-1

Basic information

• Product Name: 5-Benzyl-1-oxa-5-azaspiro[2.5]octane
• Synonyms: 5-Benzyl-1-oxa-5-azaspiro[2.5]octane
• CAS NO: 97267-35-1
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203
• Mol File: 97267-35-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 301℃
• Flash Point: 89℃
• Appearance: /
• Density: 1.12
• CAS DataBase Reference: 5-Benzyl-1-oxa-5-azaspiro[2.5]octane(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzyl-1-oxa-5-azaspiro[2.5]octane(97267-35-1)
• EPA Substance Registry System: 5-Benzyl-1-oxa-5-azaspiro[2.5]octane(97267-35-1)

Safety Data

• Hazardous Substances Data: 97267-35-1(Hazardous Substances Data)

Upstream product

• 40114-49-6 1-benzyl-3-piperidone 
• 1774-47-6 trimethylsulfoxonium iodide 
• 2181-42-2 trimethylsulphonium iodide 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 
• 50606-58-1 N-benzyl-3-piperidinone hydrochloride 
• 70775-39-2 dimethylsulfoxonium methylide 

Downstream Products

• 885268-85-9 C₁₃H₂₀N₂O 
• 405089-24-9 1-benzyl-3-(4-trifluoromethyl-phenoxymethyl)-piperidin-3-ol 
• 112197-89-4 3-hydroxy-3-(hydroxymethyl)-1-(phenylmethyl)piperidine 
• 104778-52-1 3-<(2-ethoxyphenoxy)methyl>-3-piperidinol 
• 104778-56-5 1-acetyl-3-<(2-ethoxyphenoxy)methyl>-3-piperidinol 
• 104778-55-4 1-benzyl-3-<(2-ethoxyphenoxy)methyl>-3-piperidinol 

Relevant articles and documents

PROGRANULIN MODULATORS AND METHODS OF USING THE SAME

Provided herein are compounds of formula (I) that modulate progranulin and methods of using the compounds in progranulin- associated disorders, such as Frontotemperal lobe dementia (FTLD).

QUINOLONE ANTIBACTERIAL AGENTS

Compounds of formula (I, II, III, IV, V, and VI) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications including use as antibacterial agents.

THERAPEUTIC AGENT FOR RESPIRATORY DISEASE CONTAINING 4-HYDROXYPIPERIDINE DERIVATIVE AS ACTIVE INGREDIENT

An agent for preventing/treating respiratory diseases contains, as an active ingredient, a compound represented by following Formula (I): wherein A is a group represented by L-W [wherein L is a bond or CH2; and W is O, SOn (wherein n is 0 to 2), or -NR7-(wherein R7 is hydrogen or lower alkyl)]; each of G1 and G2 is (CH2)r (wherein r is 0 to 2), provided that when n is 1, G1 and G2 may be bridged by lower alkylene; Y is a lower alkylene or (substituted) benzylidene; Z is a bond or O, provided that when Z is a bond, Y may form a 5- or 6-membered ring with carbon on the benzene ring; R1 is, for example, NO2, a lower alkoxycarbonyl, (substituted) carbamoyl, (protected) hydroxyl group, (protected) carboxyl, or (protected) N-hydroxycarbamoyl; each of R2and R3 is hydrogen, halogen, (halogenated) lower alkyl, (halogenated) lower alkoxy or NO2; each of R4 and R5 is, for example, hydrogen, halogen, (halogenated) lower alkyl, (halogenated) lower alkoxy, CN, or lower alkylsulfonyl; and R6 is hydrogen or lower alkyl, a salt thereof or a solvate of them. It has excellent antitussive activity when used as an agent for preventing/treating respiratory diseases such as lung cancer, common cold syndrome, pulmonary tuberculosis, pneumonia, acute bronchitis or chronic bronchitis.