97351-96-7

Basic information

• Product Name: N,N-Dipropyl-3-nitro-benzeneethanaMine
• Synonyms: N,N-Dipropyl-3-nitro-benzeneethanaMine;3-nitro-N,N-dipropylbenzeneethanamine
• CAS NO: 97351-96-7
• Molecular Formula: C₁₄H₂₂N₂O₂
• Molecular Weight: 250.33668
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 97351-96-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: N,N-Dipropyl-3-nitro-benzeneethanaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dipropyl-3-nitro-benzeneethanaMine(97351-96-7)
• EPA Substance Registry System: N,N-Dipropyl-3-nitro-benzeneethanaMine(97351-96-7)

Safety Data

• Hazardous Substances Data: 97351-96-7(Hazardous Substances Data)

Usage

Uses

Intermediate in the preparation of Ropinirole derivatives.

Upstream product

• 66146-33-6 2-(3-nitrophenyl)acetaldehyde 
• 142-84-7 di-n-propylamine 
• 1877-73-2 3-nitro-benzeneacetic acid 
• 38411-41-5 (3-nitrophenyl)acetyl chloride 
• 97351-97-8 N,N-di-n-propyl-2-(3-nitrophenyl)acetamide 
• 69628-97-3 toluene-4-sulfonic acid 2-(3-nitrophenyl)ethyl ester 

Downstream Products

• 942913-61-3 2-[2-(di-n-propylamino)ethyl]-6-nitro-phenylacetonitrile 
• 103544-23-6 3'-<2-(N,N-di-n-propylamino)ethyl>aniline 

Relevant articles and documents

Novel process for ropinirole preparation

A method for producing compounds of the formula: Wherein R2 is selected from the group consisting of amino, lower alkylamino, di-lower alkylamino, allylamino, diallylamino, N-lower alkyl-N-allylamino, benzylamino, dibenzylamino, phenethylamino, diphenethylamino, 4-hydroxyphenethylamino or di-(4-hydroxyphenethylamino); comprising: a) reacting with Wittig Reagent to produce wherein R1 is alkoxyl; f) hydrolyzing compound II under acidic conditions to produce g) subjecting compound III to reduction and amination to produce the tertiary amine wherein R2 is as defined above; h) reacting compound IV with 4-chlorophenoxyacetonitrile to create nucleophilic substitution to produce the nitrile compound wherein R2 is as defined above; and i) effecting reduction and hydrolysis in the same step with palladium/C and sodium hydroxide to produce wherein R2 is as defined above.

4--2(3H)-indolone: A Prejunctional Dopamine Receptor Agonist

4--2(3H)-indolone (1c) (SK and F 101468) is a potent and selective prejunctional dopamine receptor agonist.It caused a dose-related inhibition of the constrictor response to electrical stimulation in the isolated perfused rabbit ear artery (EC50 = 100 nM), and this response was antagonized by (S)-sulpiride (KB = 7 nM).Compound 1c did not stimulate or block dopamine-sensitive adenylate cyclase and did not produce stimulation of the central nervous system in rats.It was prepared from (2-methyl-3-nitrophenyl)acetic acid in a multistep sequence based on the Reissert indole synthesis.