97455-05-5Relevant articles and documents
Microbial hydroxylation of steroids. 11. Hydroxylation of A-nor-, B-homo-Δ1-, and Δ1-testosterone acetates by Rhizopus arrhizus
Holland, Herbert L.,Chenchaiah, P. Chinna
, p. 1127 - 1131 (2007/10/02)
The testosterone derivatives A-nortestosterone acetate and B-homo-Δ1-testosterone acetate have been incubated with Rhizopus arrhizus, a fungus which hydroxylates testosterone at the C-6β and C-11α positions.These modes of hydroxylation were also observed for the A-nor steroid.The B-homo steroid, however, was oxidized at C-2β and concurrently hydroxylated at C-6β and C-7aβ (but not at C-11) by R. arrhizus. Δ1 steroids of conventional skeleton were hydroxylated at C-11α by R. arrhizus; in addition, Δ1-androstenedione was epoxidized at the 1,2β position.No C-6 hydroxylation of conventional Δ1,4-3-ketosteroids was observed..