97561-04-1Relevant articles and documents
Efficient Preparation of Alkaloids Polycarpine and Polycarpaurines A and C
Guo, Pengbin,Yan, Shuang,Hu, Zeliang,Zhuang, Weihui,Xiong, Yan,Zhang, Lanya,Wang, Ziwen,Wang, Qingmin
, p. 121 - 124 (2017/02/05)
An efficient method for the preparation of alkaloids polycarpine and polycarpaurines A and C via microwave-assisted three-step one-pot reaction as the key step has been developed. This is the first report about the synthesis of polycarpaurines A and C. Starting from commercially available p-methoxybenzaldehyde, polycarpine and polycarpaurine A were obtained over seven steps with 40 and 24 % overall yield, respectively. Polycarpine could convert to polycarpaurine C in 72% yield in the presence of NaHSO3. The structure of polycarpine and polycarpaurines A and C was confirmed by1H NMR,13C NMR, and HRMS.