97608-49-6

Basic information

• Product Name: 2,6-Dichelorotrifluoromethoxybenzene
• Synonyms: 2,6-Dichelorotrifluoromethoxybenzene;1,3-dichloro-2-(trifluoromethoxy)benzene;2,6-Dichlorophenyl trifluoromethyl ether;1,3-Dichloro-2-(trifluoromethoxy);2,6-dichloro-1-(trifluoromethoxy)benzen
• CAS NO: 97608-49-6
• Molecular Formula: C₇H₃Cl₂F₃O
• Molecular Weight: 230.9993296
• Mol File: 97608-49-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,6-Dichelorotrifluoromethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichelorotrifluoromethoxybenzene(97608-49-6)
• EPA Substance Registry System: 2,6-Dichelorotrifluoromethoxybenzene(97608-49-6)

Safety Data

• Hazardous Substances Data: 97608-49-6(Hazardous Substances Data)

Usage

Description

2,6-Dichelorotrifluoromethoxybenzene is an organic compound that serves as a valuable synthetic intermediate in the chemical industry. It is characterized by its unique molecular structure, featuring two chlorine atoms and a trifluoromethoxy group attached to a benzene ring. 2,6-Dichelorotrifluoromethoxybenzene plays a crucial role in the synthesis of various pharmaceuticals and other organic compounds.

Uses

Used in Pharmaceutical Synthesis:
2,6-Dichelorotrifluoromethoxybenzene is used as a synthetic intermediate for the production of 4-Chloro-3-(trifluoromethoxy)aniline (C421915), a compound with potential applications in the pharmaceutical industry.
Used in Inflammatory Disease Treatment:
In the field of medicinal chemistry, 2,6-Dichelorotrifluoromethoxybenzene is utilized as a reagent in the preparation of diazepanone compounds. These compounds act as chemokine receptor antagonists, which are essential in the treatment of inflammatory diseases by modulating the immune response and reducing inflammation.
Used in Chemical Synthesis:
2,6-Dichelorotrifluoromethoxybenzene is also employed as a key intermediate in the synthesis of other organic compounds, contributing to the development of new materials and chemical products across various industries.

InChI:InChI=1S/C7H3Cl2F3O/c8-4-2-1-3-5(9)6(4)13-7(10,11)12/h1-3H

Upstream product

• 541-73-1 1,3-Dichlorobenzene 
• 1984-65-2 2,6-dichloroanisole 
• 87-65-0 2,6-Dichlorophenol 
• 97608-48-5 1,3-Dichloro-2-trichloromethoxy-benzene 

Downstream Products

• 97608-50-9 4-chloro-3-(trifluoromethoxy) aniline 
• 1437779-74-2 2-(3,5-dichloro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1437779-75-3 1,3-dichloro-2-(trifluoromethoxy)-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 1437779-34-4 5-(5-(3,5-Dichloro-4-(trifluoromethoxy)phenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol 

Relevant articles and documents

DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME

The present invention provides a compound having the structure (I), a processing of making the compound; and a process of using the compound as a reagent for the difluoromethoxylation and trifluoromethoxylation of arenes or heteroarenes.

A safe and economical synthesis of 3-(trifluoromethoxy) aniline from 2-chlorophenol

A simple, safe and realistic synthesis of 3-(trifluoromethoxy) aniline from 2-chlorophenol is proposed, the key step being a regiospecific arynic amination of 2-chloro (trifluoromethoxy) benzene.This method has been extended to the synthesis of 4-chloro-3-(trifluoromethoxy) aniline from 2,6-dichlorophenol.Some unusual products are obtained during the reaction between sodium amide and 2-chloro (chlorodifluoromethoxy) benzene, the formation of which is discussed.