97618-99-0Relevant articles and documents
A facile synthesis of β-amino carbonyl compounds through an aza-Michael addition reaction under solvent-free conditions
Huang, Chao,Yin, Yanqing,Guo, Jiahui,Wang, Jiong,Fan, Baomin,Yang, Lijuan
, p. 10188 - 10195 (2014/03/21)
An efficient and eco-friendly process for the synthesis of β-amino carbonyl compounds was introduced in this paper. The oxanorbornene β-amino esters and β-enamine esters were successfully prepared from oxabornene and amines by using solvent-free aza-Michael addition reaction in the absence of any catalyst. Oxanorbornene β-amino esters were the major product at room temperature, but higher temperature (e.g. 90 °C) led to the formation of β-enamine esters. In addition, all of the target compounds were characterized by IR, 1H NMR, 13C NMR, and HR-MS. A possible reaction pathway was also proposed.
