97928-18-2

Basic information

• Product Name: 1-[3-(4-tert-Butylbenzoyl)propyl]-4-hydroxypiperidine
• Synonyms: 1-[4-(1,1-Dimethylethyl)phenyl]-4-(4-hydroxy-1-piperidinyl)-1-butanone;Ebastine Related CoMpound D;1-[4-(1,1-Dimethylethyl)phenyl]-4-(4-hydroxypiperidin-1-yl)butan-1-one;1-(4-(tert-Butyl)phenyl)-4-(4-hydroxypiperidin-1-yl)butan-1-one
• CAS NO: 97928-18-2
• Molecular Formula: C19H29NO2
• Molecular Weight: 303.44
• EINECS: 619-298-4
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 97928-18-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 70-73°C
• Boiling Point: 450.832 °C at 760 mmHg
• Flash Point: 226.455 °C
• Appearance: Off-White Solid
• Density: 1.042
• Storage Temp.: Refrigerator
• PKA: 14.87±0.20(Predicted)
• CAS DataBase Reference: 1-[3-(4-tert-Butylbenzoyl)propyl]-4-hydroxypiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-(4-tert-Butylbenzoyl)propyl]-4-hydroxypiperidine(97928-18-2)
• EPA Substance Registry System: 1-[3-(4-tert-Butylbenzoyl)propyl]-4-hydroxypiperidine(97928-18-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 97928-18-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Ebastine intermediate

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 43076-61-5 4'-tert-butyl-4-chlorobutyrophenone 

Relevant articles and documents

PROCESS OF PREPARING EBASTINE

The present invention relates to a novel process for the preparation of pure Ebastine and use of the same in formulation without micronising. The invention further relates to the process of preparation of 1 -[4-(1, 1 -dimethyl ethyl) phenyl] -4-(4-hydroxy piperidin-1-yl) butan-1-one (compound II), an intermediate or preparation of Ebastine and use of the same in the preparation of pure Ebastine with the maximum particle size more than 1000 μm and D90 from 250 μm -1000 μm.

PROCESS OF PREPARING EBASTINE

The present invention relates to a novel process for preparing ebastine from 1-[4-(1,1-dimethylethyl) phenyl]-4-(4-hydroxy piperidin-1-yl) butan-1-one and diphenyl methanol, which is easily reproducible on an industrial scale. A process for preparation of 1-[4-(1,1-dimethylethyl) phenyl]-4-(4-hydroxy piperidin-1-yl) butan-1-one.