97950-75-9Relevant articles and documents
PROCESS FOR THE SYNTHESIS OF DISTAMYCIN AND DERIVATIVES THEREOF USING 1-METHYL-4-FORMYLAMINO-2-PYRROLECARBONYL CHLORIDE ITERATIVELY AS AN INTERMEDIATE
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Page 13-14, (2008/06/13)
A process for the total synthesis of Distamycin, and synthetic poly-(4 aminopyrrole -2-carboxamide) congeners thereof, using 1-methyl-4-- forinylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate, is provided. The process finds application for both in solution and solid support synthetic technologies.
Synthesis of novel thiazole-containing DNA minor groove binding oligopeptides related to the antibiotic distamycin
Rao,Bathini,Lown
, p. 728 - 737 (2007/10/02)
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Efficient Total Syntheses of the Oligopeptide Antibiotics Netropsin and Distamycin
Lown, J. William,Krowicki, Krzysztof
, p. 3774 - 3779 (2007/10/02)
New and efficient total syntheses of the natural oligopeptide antiviral antibiotics netropsin and distamycin are described.These procedures feature a different strategy of introduction of the terminal groups from that used hitherto, high yield coupling steps, improvements in the Pinner reaction for introducing the amidine moiety, and the novel use of N-formylimidazole for introduction of the formyl moiety in distamycin.The methods also avoid column chromatography with the attendant contamination of the oligopeptide hydrochlorides with inorganic salts eluted from adsorbents.The synthetic procedures are general and may be adapted to the synthesis of related oligopeptide structures.