97961-94-9Relevant articles and documents
Transfer hydrogenation of nitrogen heterocycles using a recyclable rhodium catalyst immobilized on bipyridine-periodic mesoporous organosilica
Matsui, Kazuma,Maegawa, Yoshifumi,Waki, Minoru,Inagaki, Shinji,Yamamoto, Yoshihiko
, p. 534 - 539 (2018)
Transfer hydrogenation of unsaturated nitrogen heterocycles using a rhodium catalyst immobilized on bipyridine-periodic mesoporous organosilica (BPy-PMO) is described. The immobilized catalyst was prepared by mixing [Cp?RhCl2]2 (Cp?
Dearomatizing Spiroannulation Reagents: Direct Access to Spirocycles from Indoles and Dihalides
Liddon, John T. R.,Rossi-Ashton, James A.,Taylor, Richard J. K.,Unsworth, William P.
, p. 3349 - 3353 (2018/06/11)
Unfunctionalized indoles can be directly converted into 3,3′-spirocyclic indolenines and indolines upon reaction with electrophilic dihalides in the presence of t-BuOK/BEt3. This double C-C bond forming reaction, which simultaneously generates a quaternary spirocyclic center, typically proceeds in high yield and has good functional group tolerance. In contrast to existing dearomatizing spirocyclization approaches, there is no need to prepare a prefunctionalized aromatic precursor, enabling faster access to valuable spirocyclic products from simple, commercially available aromatics in one step.
REACTION OF SPIRO WITH GRIGNARD REAGENTS IN THE PRESENCE OF CUPROUS CHLORIDE
Rodriguez, Gonzalo,Benito, Yolanda,Temprano, Fernando
, p. 427 - 428 (2007/10/02)
Attack of MeMgI and PhMgBr in toluene on spiro (1) in the presence of Cu2Cl2 gives 2'-substituted spiro in quantitative yields.Also, attack of PhCH2CH2MgBr on 1 in the presence of Cu2Cl2 afforded 2'-phenethyl, 2'-H and 2'-benzyl (or 2'-p-xylyl) derivatives in toluene (or p-xylene) as solvent.
