98-17-9Relevant articles and documents
A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh2andtBuOK
Pan, Wenjing,Li, Chenchen,Zhu, Haoyin,Li, Fangfang,Li, Tao,Zhao, Wanxiang
, p. 7633 - 7640 (2021/09/22)
A general method for the demethylation, debenzylation, and deallylation of aryl ethers using HPPh2andtBuOK is reported. The reaction features mild and metal-free reaction conditions, broad substrate scope, good functional group compatibility, and high chemical selectivity towards aryl ethers over aliphatic structures. Notably, this approach is competent to selectively deprotect the allyl or benzyl group, making it a general and practical method in organic synthesis.
Highly efficient heterogeneous V2O5@TiO2 catalyzed the rapid transformation of boronic acids to phenols
Upadhyay, Rahul,Singh, Deepak,Maurya, Sushil K.
supporting information, p. 3925 - 3931 (2021/08/24)
A V2O5@TiO2 catalyzed green and efficient protocol for the hydroxylation of boronic acid into phenol has been developed utilizing environmentally benign oxidant hydrogen peroxide. A wide range of electron-donating and the electron-withdrawing group-containing (hetero)aryl boronic acids were transformed into their corresponding phenol. The methodology was also applied successfully to transform various natural and bioactive molecules like tocopherol, amino acids, cinchonidine, vasicinone, menthol, and pharmaceuticals such as ciprofloxacin, ibuprofen, and paracetamol. The other feature of the methodology includes gram-scale synthetic applicability, recyclability, and short reaction time.
Synthetic method of m-trifluoromethylphenol
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Paragraph 0022; 0026-0029; 0032-0034; 0037-0041, (2021/11/03)
The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of m-trifluoromethylphenol. The method comprises the following steps: (1) in a solvent, carrying out Williamson reaction on m-chlorobenzotrifluoride and tert-butyl alcohol under the catalysis of sodium hydride and metal acetate to prepare an intermediate m-trifluoromethylbenzene tert-butyl ether; (2) in a solvent, carrying out tertiary butyl removal on the m-trifluoromethyl benzene tert-butyl ether prepared in the step (1) under the action of a ZSM-5 molecular sieve to prepare the trifluoromethylphenol. The synthesis steps are simple, the cost is low, and the process is more environment-friendly.