98-57-7

Basic information

• Product Name: 4-Methylsulfuryl chlorobenzene
• Synonyms: 1-chloro-4-(methylsulfonyl)-benzen;1-chloro-4-(methylsulfonyl)benzene;4-Methylsulfonylchlorobenzene;methyl4-chlorophenylsulfone;methylp-chlorophenylsulfone;sulfone,p-chlorophenylmethyl;TIMTEC-BB SBB006326;P-CHLOROPHENYL METHYL SULFONE
• CAS NO: 98-57-7
• Molecular Formula: C₇H₇ClO₂S
• Molecular Weight: 190.65
• EINECS: 202-682-7
• Product Categories: Sulfur Compounds (for Synthesis);Synthetic Organic Chemistry;Organic Building Blocks;Sulfones;Sulfur Compounds;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds
• Mol File: 98-57-7.mol
• Article Data: 178

Chemical Properties

• Melting Point: 95-98 °C(lit.)
• Boiling Point: 60 °C / 30mmHg
• Flash Point: 153.5 °C
• Appearance: Off-white/Crystalline Powder
• Density: 1.3264 (estimate)
• Vapor Pressure: 5.86E-10mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: 2-8°C
• BRN: 638281
• CAS DataBase Reference: 4-Methylsulfuryl chlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylsulfuryl chlorobenzene(98-57-7)
• EPA Substance Registry System: 4-Methylsulfuryl chlorobenzene(98-57-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-38
• Safety Statements: 26-28-36/37/39-24/25
• WGK Germany: 3
• RTECS: WR5730000
• TSCA: Yes
• Hazardous Substances Data: 98-57-7(Hazardous Substances Data)

Usage

Chemical Properties

off-white crystalline powder

Uses

4-Chlorophenyl methyl sulfone may be used in the preparation of 4-(methylsulfonyl)aniline by reacting with ammonia. It may also be used as a standard during the quantification of 4-chlorophenyl methyl sulphide by HPLC in rat liver microsomes.

General Description

4-Chlorophenyl methyl sulfone (CPMSO2) is a sulfone analog of 4-chlorophenyl methyl sulfide. It is used as an intermediate for preparing sulfur-containing xenobiotics.

InChI:InChI=1/C14H12Cl2O2S/c15-13-5-1-11(2-6-13)9-19(17,18)10-12-3-7-14(16)8-4-12/h1-8H,9-10H2

Upstream product

• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 79-11-8 chloroacetic acid 
• 77-78-1 dimethyl sulfate 
• 108-90-7 chlorobenzene 
• 7143-01-3 Methanesulfonic anhydride 
• 106-54-7 p-Chlorothiophenol 
• 123-09-1 4-chlorophenyl methyl sulfide 
• 164021-74-3 (1S,2R)-(-)-2-[N-(3’,5’-di-tert-butylsalicylidene)amino]-1,2-diphenylethanol 
• 106-39-8 bromochlorobenzene 
• 67-68-5 dimethyl sulfoxide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 3405-88-7 (4-chlorophenylthio)acetic acid 
• 3996-47-2 4-Chlorophenylsulfenylacetic acid 
• 20277-69-4 sodium methansulfinate 

Downstream Products

• 150221-20-8 1-(4-(methylsulfonyl)phenyl)piperidine 
• 63029-15-2 (4-(methylsulfonyl)phenyl)(phenyl)sulfane 
• 58940-96-8 Aethoxy-oxalyl-methyl-p-chlorphenyl-sulfon 
• 877-66-7 4-(methylsulfonyl)phenylhydrazine 
• 83642-21-1 4-(4-(methylsulfonyl)phenoxy)-1-chlorobenzene 
• 521097-86-9 CH₃SO₂C₆H₄ZnCl 
• 3112-85-4 methylphenylsulfonate 
• 134368-62-0 4,4'-bis-methanesulfonyl-biphenyl 
• 313553-46-7 4'-(methylsulfonyl)-[1,1'-biphenyl]-4-carboxylic acid methyl ester 
• 792-74-5 4,4'-biphenyldicarboxylic acid dimethyl ester 
• 1374126-09-6 C₁₅H₁₀Br₃N₃O₃S₂ 
• 1374126-10-9 C₁₅H₉Br₃ClN₃O₃S₂ 
• 1374125-65-1 C₇H₃Br₃ClNO₄S 
• 1393937-27-3 4-(tert-butylthio)phenyl methyl sulfone 

Relevant articles and documents

Crystal and molecular structure of methyl-(4-chlorophenyl)sulfone

Sulfones are known to be biologically active compounds. X-ray diffraction is used to determine the crystal and molecular structure of methyl-(4-chlorophenyl)sulfone. The closest molecules are in pairs oriented to each other by their chlorine atoms. The cr

Method for synthesizing aryl alkyl sulfone compound by promoting oxidation of aryl alkyl thioether compound through visible light

The invention discloses a method for synthesizing an aryl alkyl sulfone compound by promoting oxidation of an aryl alkyl thioether compound through visible light. The method comprises the following steps of: performing one-pot reaction on an aryl alkyl thioether compound and sodium trifluoromethanesulfinate in a diethylene glycol dibutyl ether solution system under the conditions of oxygen-containing atmosphere and 385-390 nm purple light irradiation to generate the aryl alkyl sulfone compound. The method has the advantages of mild conditions, simple operation, environmental protection, easilyavailable raw materials, excellent compatibility of substrate functional groups, high reaction yield and the like.

PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF

The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that are based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.