98059-61-1 Usage
Description
Interferon gamma-lb, a recombinant DNA product, has orphan drug status for the
treatment of chronic granulomatous disease. It is also under investigation as a
treatment for trauma-related infections and atopic dermatitis.
Uses
Antineoplastic; biological response modifier; immunoregulator.
Brand name
Actimmune
General Description
Interferon gamma-1b, Actimmune, is a recombinant proteinexpressed in E. coli. IFN-γ is the cytokine that is secreted byhuman T lymphocytes and NK cells. It is a single-chain glycoproteincomposed of 140 amino acids. The crystal structure of the protein reveals several helical segments arranged toapproximate a toric shape.Interferon gamma-1b is indicated for reducing the frequencyand severity of serious infections associated withchronic granulomatous disease, an inherited disorder characterizedby deficient phagocyte oxidase activity. In this disease,macrophages try to respond to invading organisms butlack the key oxidative enzymes to dispose of them. To compensate,additional macrophages are recruited into the infectedregion and form a granulomatous structure around thesite. IFN-γ can stimulate the oxidative burst in macrophagesand may reverse the situation.Interferon gamma-1b is supplied as a solution in sterilewater for injection. The solution must be stored at 2°C to8°C, without freezing. The product cannot tolerate morethan 12 hours at room temperature.
Clinical Use
Adjunct to antibiotics to reduce the frequency of serious
infections in patients with chronic granulomatous disease
Drug interactions
Potentially hazardous interactions with other drugs
Avoid with vaccines.
Metabolism
The metabolism of cloned interferons falls within the
natural handling of proteins. Interferon gamma-1b
was not detected in the urine of healthy male subjects
following administration via IV, IM or SC routes. In vitro
hepatic and renal perfusion studies demonstrate that
the liver and kidneys are capable of clearing interferon
gamma-1b from perfusate.
Interferon is metabolised primarily in the kidney. It is
excreted in the urine, but is reabsorbed by the tubules
where it undergoes lysosomal degradation.
Check Digit Verification of cas no
The CAS Registry Mumber 98059-61-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,0,5 and 9 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 98059-61:
(7*9)+(6*8)+(5*0)+(4*5)+(3*9)+(2*6)+(1*1)=171
171 % 10 = 1
So 98059-61-1 is a valid CAS Registry Number.