98081-75-5Relevant articles and documents
A telescoped protocol for the synthesis of new pyrrolo [3,4-d]pyridazinones by cascade reactions
Bonacorso, Helio G.,Libero, Francieli M.,Dal Forno, Gean M.,Pittaluga, Everton P.,Porte, Liliane M.F.,Martins, Marcos A.P.,Zanatta, Nilo
supporting information, p. 5190 - 5195 (2015/08/19)
A new one-pot method, for the synthesis of polysubstituted pyrrolo[3,4-d]pyridazinones, is presented. The protocol consists in cascade reactions performed in the same media: (i) the thermal in situ pyrrole formation by the reaction of vinyl azides with 1,
Extending the versatility of the Hemetsberger-Knittel indole synthesis through microwave and flow chemistry
Ranasinghe, Nadeesha,Jones, Graham B.
, p. 1740 - 1742 (2013/04/10)
Microwave, flow and combination methodologies have been applied to the synthesis of a number of substituted indoles. Based on the Hemetsberger-Knittel (HK) process, modifications allow formation of products rapidly and in high yield. Adapting the methodology allows formation of 2-unsubstituted indoles and derivatives, and a route to analogs of the antitumor agent PLX-4032 is demonstrated. The utility of the HK substrates is further demonstrated through bioconjugation and subsequent ring closure and via Huisgen type [3+2] cycloaddition chemistry, allowing formation of peptide adducts which can be subsequently labeled with fluorine tags.
[Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation for alkaloid synthesis using aryl azides as nitrogen source
Liu, Yungen,Wei, Jinhu,Che, Chi-Ming
supporting information; scheme or table, p. 6926 - 6928 (2010/11/16)
The syntheses of alkaloids including indoles, indolines, tetrahydroquinolines, dihydroquinazolinones and quinazolinones have been accomplished in moderate to excellent yields via [Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation using aryl azides as nitrogen source.