981-15-7 Usage
Description
Ailanthone is a quassinoid that has been found in Ailanthus and has diverse biological activities. It is active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml, respectively). Ailanthone is phytotoxic, inhibiting radish seed germination by 88% when used at a concentration of 1 mM. It inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 androgen receptor-expressing cells, but not androgen receptor-negative PC3 and DU145 cells, when used at a concentration of 0.1 μM. Ailanthone (2 mg/kg) reduces tumor volume in 22Rv1, LNCaP, and VCaP castration-resistant prostate cancer (CRPC) mouse xenograft models.
Uses
Ailanthone has potent antineoplastic activity against anti-hepatocellular carcinoma (HCC) and has been shown to inhibit Huh7 cancer cell growth through cell cycle arrest and apoptosis in vitro and in vivo.
Check Digit Verification of cas no
The CAS Registry Mumber 981-15-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,8 and 1 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 981-15:
(5*9)+(4*8)+(3*1)+(2*1)+(1*5)=87
87 % 10 = 7
So 981-15-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H24O7/c1-8-4-12(21)16(24)18(3)10(8)5-13-19-7-26-20(25,17(18)19)15(23)9(2)11(19)6-14(22)27-13/h4,10-11,13,15-17,23-25H,2,5-7H2,1,3H3/t10-,11-,13+,15+,16+,17+,18+,19+,20-/m0/s1
981-15-7Relevant articles and documents
Structure Determination of Bitter Principles in Ailanthus altissima. Structure of Shinjulactone A and Revised Structure of Ailanthone
Naora, Hirokazu,Ishibashi, Masami,Furuno, Tetsuo,Tsuyuki, Takahiko,Murae, Tatsushi,et al.
, p. 3694 - 3698 (1983)
The structure of a new bitter principle, shinjulactone A, isolated from Ailanthus altissima SWINGLE was determined to be 11β,20-epoxy-1β,2α,11α,12α-tetrahydroxypicrasa-3,13(21)-dien-16-one and the configuration of a hydroxyl group at C-12 of ailanthone was revised to α-orientation by X-ray analysis.
