98116-88-2Relevant articles and documents
Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi
Amaral, Maiara,Romanelli, Maiara M.,Tempone, Andre G.,Varela, Marina T.,de Castro Levatti, Erica V.,Fernandes, Jo?o Paulo S.
, (2022/01/31)
Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without efficient treatment for chronic patients. Despite the efforts, no new drugs have been approved for this disease in the last 60 years. Molecular modifications based on
Derivative of dihydroxybenzamide and a pharmaceutical composition having an anti-inflammatory activity
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, (2008/06/13)
Disclosed herein are a derivative of dihydroxybenzamide represented by the formula(I): STR1 wherein (1) R1 represents a hydrogen atom or a lower alkyl group and R2 represents a straight chain-alkyl group of 4 to 12 carbon atoms, a branched chain-alkyl group of 4 to 12 carbon atoms, a cyclo-alkyl group of 4 to 12 carbon atoms, STR2 wherein n is an integer of 1 to 6, or a pyridyl group which is substituted or unsubstituted, or (2) R1 and R2 are cyclized to make a heterocycle containing amino group represented by the formula STR3 wherein X represents a nitrogen atom or a methine and Y represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms or a phenyl group, and a pharmaceutical composition containing the same.
