98153-12-9

Basic information

• Product Name: 3-IODO-2-PHENYL-CHROMEN-4-ONE
• Synonyms: 3-IODO-2-PHENYL-CHROMEN-4-ONE
• CAS NO: 98153-12-9
• Molecular Formula: C₁₅H₉IO₂
• Molecular Weight: 348.13523
• Product Categories: pharmacetical
• Mol File: 98153-12-9.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-IODO-2-PHENYL-CHROMEN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-2-PHENYL-CHROMEN-4-ONE(98153-12-9)
• EPA Substance Registry System: 3-IODO-2-PHENYL-CHROMEN-4-ONE(98153-12-9)

Safety Data

• Hazardous Substances Data: 98153-12-9(Hazardous Substances Data)

Upstream product

• 525-82-6 FLAVONE 
• 16619-68-4 1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one 
• 16619-66-2 1-(2-methoxyphenyl)-3-phenylprop-2-yn-1-one 
• 98-88-4 benzoyl chloride 
• 4010-33-7 2-acetylphenyl benzoate 
• 16619-51-5 2'-allyloxychalcone 
• 536-74-3 phenylacetylene 
• 245322-93-4 1-(2-methoxyphenyl)-3-phenylprop-2-yn-1-ol 
• 4440-01-1 lithium phenylacetylide 
• 135-02-4 ortho-anisaldehyde 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 90-02-8 salicylaldehyde 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 17317-75-8 3-benzylamino-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 

Downstream Products

• 525-82-6 FLAVONE 
• 1234675-39-8 11-((2,6-diisopropylphenyl)imino)indeno[1,2-b]chromen-10(11H)-one 
• 1431842-00-0 ethyl 2,2-difluoro-2-(4-oxo-2-phenyl-4H-chromen-3-yl)-acetate 
• 1839-72-1 2-phenylbenzofuran 
• 6880-06-4 3,3''-biflavone 

Relevant articles and documents

Iodine-mediated direct synthesis of 3-iodoflavones

Molecular iodine has been used for the regioselective, one pot, direct synthesis of 3-iodoflavones from 2′-allyloxy chalcones, 2′-hydroxy chalcones and flavones. Allyl deprotection, cyclization dehydrogenation and α-iodination of 2′-allyloxychalcones has been achieved in a single step to offer 3-iodoflavones.

Hypervalent iodine compound containing heterocyclic ring as well as preparation method and application thereof

The invention discloses a hypervalent iodine compound containing a heterocyclic ring as well as a preparation method and application thereof. A structure of the compound is shown as a formula (I): theformula (I) is shown in the description, wherein R is selected from hydrogen, halogen, alkyl, alkoxy, halogenated alkyl, halogenated alkoxy, nitryl, cyano, hydroxyl or -COOR'; R' is alkyl or halogenated alkyl; and Het is substituted or non-substituted 1,4-benzopyranone, substituted or non-substituted quinolone, substituted or non-substituted isoquinoline, substituted or non-substituted thiobenzopyranone, substituted or non-substituted coumarin and substituted or non-substituted oxepin. The compound disclosed by the invention is novel in structure and is the hypervalent iodine compound containing the heterocyclic ring; the hypervalent iodine compound is stable in structure and simple in preparation method; and meanwhile, the hypervalent iodine compound has a very good inhibition effect onML-1 and MOLM-13 cells and has an extremely great application prospect on prevention and/or treatment effect on leukemia.

New gas-phase domino processes leading to benzopyranones and benzofurans

A new domino approach to flavones by gas phase pyrolysis of β,γ-dioxophosphonium ylides containing a 2-methoxyphenyl group is frustrated by unexpected and novel decarbonylation of the intermediate flavon-3-yl radical leading to 2-phenylbenzofuran. Alternative approaches based on dioxolane protection of one carbonyl, or selective elimination in β,β′-dioxo or β-oxo-β′-thioxo ylides were not successful, but pyrolysis of a β-oxo-β′-phenylimino ylide did give the required domino reaction leading to a protected benzopyranone in moderate yield.