98175-84-9Relevant articles and documents
Reduction of imidazo[4,5-c]pyridine and [1,2,3]triazolo[4,5-c]pyridine derivatives to spinaceamines and 2-azaspinaceamines
Yutilov,Smolyar,Astashkina
, p. 419 - 423 (2002)
Reduction of 1-substituted [1,2,3]triazolo[4,5-c]pyridines with nickel-aluminum alloy in aqueous alkali gave 2-azaspinaceamines. Reduction of imidazo[4,5-c]pyridine and [1,2,3]triazolo[4,5-c]pyridine derivatives with formic acid in the presence of triethy
Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists
Savall, Brad M.,Wu, Duncan,De Angelis, Meri,Carruthers, Nicholas I.,Ao, Hong,Wang, Qi,Lord, Brian,Bhattacharya, Anindya,Letavic, Michael A.
, p. 671 - 676 (2015/06/23)
We describe the synthesis and SAR of 1,2,3-triazolopiperidines as a novel series of potent, brain penetrant P2X7 antagonists. Initial efforts yielded a series of potent human P2X7R antagonists with moderate to weak rodent potency, some CYP inhibition, poo
SYNTHESIS OF DERIVATIVES OF 2-AZASPINACEAMINE
Yutilov, Yu. M.,Smolyar, N. N.
, p. 474 - 480 (2007/10/02)
1,5-Disubstituted 1,2,3-triazolopyridinium monoquaternary salts were obtained by the reaction of 1-substituted 1,2,3-triazolopyridines with alkyl halides and bromomethyl ketones.Their reduction with sodium borohydride in an alcohol medium led to the formation of derivatives of both 1,5-dialkyl- and N5-β-hydroxyethyl-β-aryl(alkyl)-2-azaspinaceamine.It was shown that 1-alkyl-5-(β-hydroxy-β-phenylethyl)-2-azaspinaceamines containing a methoxy group at the para position of the phenyl ring are readily cleaved at the terminal C-N5 bond when heated with hydrochloric acid in water-alcohol solution and form 1-alkyl-2-azaspinaceamines.
