98181-84-1

Basic information

• Product Name: Benzene, 1-chloro-4-[[(fluoromethyl)thio]methyl]-
• CAS NO: 98181-84-1
• Molecular Formula: C8H8ClFS
• Molecular Weight: 190.669
• Mol File: 98181-84-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 1-chloro-4-[[(fluoromethyl)thio]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-4-[[(fluoromethyl)thio]methyl]-(98181-84-1)
• EPA Substance Registry System: Benzene, 1-chloro-4-[[(fluoromethyl)thio]methyl]-(98181-84-1)

Safety Data

• Hazardous Substances Data: 98181-84-1(Hazardous Substances Data)

Upstream product

• 593-70-4 R₃₂ 
• 6258-66-8 (4-chlorophenyl)methanethiol 
• 75-45-6 Chlorodifluoromethane 

Downstream Products

• 42497-69-8 monofluoromethylsulfonyl chloride 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Relevant articles and documents

Photoredox-Catalyzed Intramolecular Difluoromethylation of N-Benzylacrylamides Coupled with a Dearomatizing Spirocyclization: Access to CF2H-Containing 2-Azaspiro[4.5]deca-6,9-diene-3,8-diones

A visible light-mediated difluoromethylation of N-benzylacrylamides with HCF2SO2Cl as the HCF2 radical precursor is described. The reaction incorporates a tandem cyclization/dearomatization process to afford various difluoromethylated 2-azaspiro[4.5]deca-6,9-diene-3,8-diones bearing adjacent quaternary stereocenters under mild conditions in moderate to excellent yields.

Photoredox-catalyzed tandem radical cyclization of N-arylacrylamides: General methods to construct fluorinated 3,3-disubstituted 2-oxindoles using fluoroalkylsulfonyl chlorides

Fluorinated radicals were generated from RfSO2Cl by photoredox catalysis under mild conditions, where Rf = n-C4F9, CF3, CF2H, CH2F, CH2CF3, and CF2CO2Me. This method provided a general way to construct fluorinated 2-oxindoles from reaction with N-arylacrylamides via a proposed tandem radical cyclization process.