98237-15-1

Basic information

• Product Name: Isoquinoline, 1-[(2-methylphenyl)methyl]-
• CAS NO: 98237-15-1
• Molecular Formula: C17H15N
• Molecular Weight: 233.313
• Mol File: 98237-15-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 1-[(2-methylphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1-[(2-methylphenyl)methyl]-(98237-15-1)
• EPA Substance Registry System: Isoquinoline, 1-[(2-methylphenyl)methyl]-(98237-15-1)

Safety Data

• Hazardous Substances Data: 98237-15-1(Hazardous Substances Data)

Upstream product

• 16576-36-6 2-benzoyl-1,2-dihydro-1-(2-methylbenzyl)isoquinoline-1-carbonitrile 
• 119-65-3 isoquinoline 
• 95-47-6 o-xylene 
• 89-92-9 2-methylbenzyl bromide 
• 844-25-7 2-benzoyl-1-cyano-1,2-dihydroisoquinoline 
• 552-45-4 1-chloromethyl-2-methylbenzene 

Downstream Products

• 54923-42-1 isoquinolin-1-yl(o-tolyl)methanol 
• 98237-24-2 1-(2-Methylbenzyl)-2-methyl-5,6,7,8-tetrahydroisochinoline 

Relevant articles and documents

Oxidant-Triggered C1-Benzylation of Isoquinoline by Iodine-Catalyzed Cross-Dehydrogenative-Coupling with Methylarenes

A practical iodine-catalyzed oxidative functionalization of isoquinolines with methylarenes is developed, which can be triggered by the selected oxidants to produce C1- or N-benzyl-substituted products selectively. This method utilizes readily available isoquinolines and methylarenes as starting materials and proceeds under metal-free conditions with broad substrate scope with respect to methylarenes, avoiding the usage of expensive metal catalysts and generation of halide and metal wastes.

C1-Benzyl and benzoyl isoquinoline synthesis through direct oxidative cross-dehydrogenative coupling with methyl arenes

An oxidative cross-dehydrogenative coupling (CDC) of isoquinolines with methyl arenes has been developed, allowing for the facile synthesis of a broad range of structurally diverse C1-benzyl and -benzoyl isoquinolines. The direct use of readily available methyl arenes as coupling partners avoids unproductive steps for preactivating the functional group installation, and is therefore attractive. The method exhibits excellent chemoselectivity, affording exclusive benzylated products in the presence of DTBP and a catalytic amount of Y(OTf)3, and yielding benzoylated ones with TBHP and a catalytic amount of MnO2.