98244-78-1

Basic information

• Product Name: 2,6-bis[(diethylamino)methyl]-4-[(10-methyl-10H-indolo[3,2-b]quinolin-11-yl)amino]phenol hydrochloride (1:1)
• Synonyms: 2,6-Bis((diethylamino)methyl)-4-((10-methyl-10H-indolo[3,2-b]quinolin-11-yl)amino)phenol hydrochloride
• CAS NO: 98244-78-1
• Molecular Formula: C₃₂H₃₉N₅O
• Molecular Weight: 546.1459
• Mol File: 98244-78-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 635.5°C at 760 mmHg
• Flash Point: 338.1°C
• Vapor Pressure: 9.59E-17mmHg at 25°C
• CAS DataBase Reference: 2,6-bis[(diethylamino)methyl]-4-[(10-methyl-10H-indolo[3,2-b]quinolin-11-yl)amino]phenol hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-bis[(diethylamino)methyl]-4-[(10-methyl-10H-indolo[3,2-b]quinolin-11-yl)amino]phenol hydrochloride (1:1)(98244-78-1)
• EPA Substance Registry System: 2,6-bis[(diethylamino)methyl]-4-[(10-methyl-10H-indolo[3,2-b]quinolin-11-yl)amino]phenol hydrochloride (1:1)(98244-78-1)

Safety Data

• Hazardous Substances Data: 98244-78-1(Hazardous Substances Data)

Usage

General Description

2,6-bis[(diethylamino)methyl]-4-[(10-methyl-10H-indolo[3,2-b]quinolin-11-yl)amino]phenol hydrochloride (1:1) is a chemical compound that consists of a phenolic structure with two diethylamino methyl groups attached to the 2 and 6 positions, and an indoloquinoline amino group attached to the 4 position. The compound is in the form of a hydrochloride salt, with a 1:1 ratio of the compound to hydrochloric acid. This chemical has potential pharmaceutical applications due to its biological activities, and it may be used in research and development for the treatment of various diseases. The compound's unique structure and properties make it an interesting subject for further study and potential therapeutic use.

Upstream product

• 73734-17-5 (1-Ethyl-1H-benzoimidazol-2-yl)-piperidin-4-yl-amine; hydrobromide 
• 86721-12-2 N--N-methylmethanaminium bromide 

Relevant articles and documents

New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines

The synthesis of a series N-(4-piperidinyl)-1H-benzimidazol-2-amines and the preliminary evaluation of their in vitro and in vivo antihistaminic activity are described. Cyclodesulfurization of (2-aminophenyl) thioureas with mercury(II) oxide resulted in 2-aminobenzimidazole intermediates, which were monoalkylated on the endo-nitrogen atom. After deprotection of the piperideine nitrogen atom with 48% aqueous hydrobromic acid solution, the title compounds were obtained by three different methods, viz. alkylation, reductive amination, or oxirane ring-opening reactions. The in vivo antihistaminic activity was evaluated by the compound 48/80 induced lethality test in rats and histamine-induced lethality test in guinea pigs after oral and/or subcutaneous administration. The duration of action, for a selected number of compounds, was studied in the guinea pig. The phenylethyl derivatives showed the most potent antihistamine properties after oral administration in both animal species.