98366-79-1

Basic information

• Product Name: β-Cyclodextrin, 6A-deoxy-6A-[(2-methoxyethyl)amino]- (9CI)
• Synonyms: β-Cyclodextrin, 6A-deoxy-6A-[(2-methoxyethyl)amino]- (9CI);6A-deoxy-6A-[(2-Methoxyethyl)aMino]-beta-Cyclodextrin
• CAS NO: 98366-79-1
• Molecular Formula: C45H77NO35
• Molecular Weight: 1192.08
• Mol File: 98366-79-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: β-Cyclodextrin, 6A-deoxy-6A-[(2-methoxyethyl)amino]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: β-Cyclodextrin, 6A-deoxy-6A-[(2-methoxyethyl)amino]- (9CI)(98366-79-1)
• EPA Substance Registry System: β-Cyclodextrin, 6A-deoxy-6A-[(2-methoxyethyl)amino]- (9CI)(98366-79-1)

Safety Data

• Hazardous Substances Data: 98366-79-1(Hazardous Substances Data)

Usage

General Description

β-Cyclodextrin, 6A-deoxy-6A-[(2-methoxyethyl)amino]- (9CI) is a chemical compound that belongs to the class of cyclodextrins, which are cyclic oligosaccharides composed of glucose molecules. This particular compound has a 6A-deoxy-6A-[(2-methoxyethyl)amino] substitution on the β-Cyclodextrin molecule. Cyclodextrins are widely used in various industrial and pharmaceutical applications, including drug delivery, food processing, and cosmetics. The substitution with 2-methoxyethylamino on the β-Cyclodextrin molecule can alter its physicochemical properties and enhance its solubility and stability, making it useful for encapsulating and delivering hydrophobic drug molecules.β-Cyclodextrin, 6A-deoxy-6A-[(2-methoxyethyl)amino]- (9CI) is a potential candidate for the development of novel drug delivery systems and other applications that require the encapsulation and controlled release of bioactive compounds.

Upstream product

• 67217-55-4 mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin 
• 109-85-3 2-methoxyethylamine 

Relevant articles and documents

TIGHT INCLUSION OF AN ACID GUEST INTO THE CAVITY OF CYCLODEXTRIN BEARING AN AMINO MOIETY IN DIMETHYL SULFOXIDE

Circular dichroism measurements show that β-cyclodextrin with an amino moiety has a strong binding ability for ferrocenecarboxylic acid in dimethyl sulfoxide via an acid-base interaction.

Nitric Oxide-Releasing Cyclodextrins

A series of secondary amine-modified cyclodextrin (CD) derivatives was synthesized with diverse exterior terminal groups (i.e., hydroxyl, methyl, methoxyl, and primary amine). Subsequent reaction with nitric oxide (NO) gas under alkaline conditions yieldedN-diazeniumdiolate-modified CD derivatives. Adjustable NO payloads (0.6-2.4 μmol/mg) and release half-lives (0.7-4.2 h) were achieved by regulating both the amount of secondary amine precursors and the functional groups around the NO donors. The bactericidal action of these NO-releasing cyclodextrin derivatives was evaluated againstPseudomonas aeruginosa, a Gram-negative pathogen, with antibacterial activity proving dependent on both the NO payload and exterior modification. Materials containing a high density of NO donors or primary amines exhibited the greatest ability to eradicateP. aeruginosa. Of the materials prepared, only the primary amine-terminated heptasubstituted CD derivatives exhibited toxicity against mammalian L929 mouse fibroblast cells. The NO donor-modified CD was also capable of delivering promethazine, a hydrophobic drug, thus demonstrating potential as a dual-drug-releasing therapeutic.