98453-58-8

Basic information

• Product Name: 7-broMo-1,1-diMethyl-1,2,3,4-tetrahydronaphthalene
• Synonyms: 7-broMo-1,1-diMethyl-1,2,3,4-tetrahydronaphthalene;2-broMo-8,8-diMethyl-5,6,7,8-tetrahydronaphthalene
• CAS NO: 98453-58-8
• Molecular Formula: C₁₂H₁₅Br
• Molecular Weight: 239.1515
• Mol File: 98453-58-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 268℃
• Flash Point: 114℃
• Appearance: /
• Density: 1.253
• CAS DataBase Reference: 7-broMo-1,1-diMethyl-1,2,3,4-tetrahydronaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 7-broMo-1,1-diMethyl-1,2,3,4-tetrahydronaphthalene(98453-58-8)
• EPA Substance Registry System: 7-broMo-1,1-diMethyl-1,2,3,4-tetrahydronaphthalene(98453-58-8)

Safety Data

• Hazardous Substances Data: 98453-58-8(Hazardous Substances Data)

Upstream product

• 87077-85-8 2-methyl-5-(4-bromophenyl)-2-pentanol 
• 563-80-4 3-methyl-butan-2-one 
• 32281-97-3 7-bromo-3,4-dihydro-2H-naphthalen-1-one 
• 544-97-8 dimethyl zinc(II) 
• 98453-57-7 4-(4-bromophenyl)butanoic acid methyl ester 
• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 35656-89-4 4-(4-bromophenyl)butanoic acid 
• 108-86-1 bromobenzene 
• 67962-10-1 1-(4'-bromophenyl)-4-methyl-1-penten-3-one 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 98453-60-2 6-bromo-3,4-dihydro-4,4-dimethylnaphthalen-1(2H)-one 
• 205385-99-5 (S)-2-{[3-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-5,5-dimethyl-5,6,7,8-tetrahydro-naphthalen-2-yl]-methyl-amino}-3-methyl-butyric acid benzyl ester 
• 98453-67-9 C₁₉H₁₉BrN₂O₂S 

Relevant articles and documents

aromatic compound having fused cyclic substituent in aromatic ring and organic light-emitting diode including the same

The present invention relates to a compound having a cyclic substituent fused with a cyclic ring and an organic light emitting diode including the same, and more particularly, to a compound for an organic light emitting diode represented by chemical formula A and an organic light emitting diode including the same. In chemical formula A, X is a substituent having structural formula X, Y is a substituent of structural formula Y1, n is an integer from 1 to 4, and structural formulas X and Y1 are the same as described in detailed description of the present invention.

Retinoid receptor subtype-selective modulators through synthetic modifications of RARγ agonists

A series of retinoids designed to interfere with the repositioning of H12 have been synthesized to identify novel RARγ antagonists based on the structure of known RARγ agonists. The transcriptional activities of the novel ligands were revealed by cell-based reporting assays, using engineered cells containg RAR subtype-selective fusions of the RAR ligand-binding domains with the yeast GAL4 activator DNA-binding domain and the cognate luciferase reporter gene. Whereas none of the ligands exhibited features of a selective RARγ antagonist, some of them are endowed with interesting activities. In particular 24a acts as a pan-RAR agonist that induces at high concentration a higher transactivation potential on RARα than TTNPB and synergizes at low concentration with TTNPB-bound RARα but not RARβ or RARγ. Similarly, 24c synergizes with TTNPB-bound RARγ and exhibits RARα,β antagonist activity. Compounds 24b and 25b are strong RARα,β-selective antagonists without agonist or antagonist activities for RARγ. Compounds 24b and 24c display weak RXR antagonist activity. In addition several pan-antagonists and partial agonist/antagonists have been defined.

Disubstituted chalcone oximes as selective agonists of RAR retinoid receptors

Compounds of the formula where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases and conditions which are responsive to RARγ agonist retinoids, such as skin related diseases, including but not limited to acne and psoriasis.