98471-36-4

Basic information

• Product Name: 3-Buten-2-one, 4,4-bis[(phenylmethyl)thio]-
• CAS NO: 98471-36-4
• Molecular Formula: C18H18OS2
• Molecular Weight: 314.472
• Mol File: 98471-36-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Buten-2-one, 4,4-bis[(phenylmethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-2-one, 4,4-bis[(phenylmethyl)thio]-(98471-36-4)
• EPA Substance Registry System: 3-Buten-2-one, 4,4-bis[(phenylmethyl)thio]-(98471-36-4)

Safety Data

• Hazardous Substances Data: 98471-36-4(Hazardous Substances Data)

Upstream product

• 218941-38-9 3-(bis(benzylthio)methylene) pentane-2,4-dione 

Downstream Products

• 1059605-45-6 4,4-bis(benzylthio)-3-(benzylthiomethyl)but-3-en-2-one 
• 1493776-55-8 1-(5-(benzylthio)-2-(trifluoromethyl)phenyl)propan-2-one 
• 5418-20-2 benzaldehyde dibenzyldithioacetal 

Relevant articles and documents

Synthesis of functionalized allylic sulfoxides and their use in the construction of 2,3,4-trisubstituted furans via a [3 + 2] annulation

(Chemical Equation Presented) A route to 2,3,4-trisubstituted furan derivatives based on a [3 + 2] annulation of functionalized allylic sulfoxides and aldehydes is described. In this strategy, the precursors of allylic sulfoxides 4, allylic sulfides 3, were synthesized via a thiomethylation reaction of an α-EWG ketene-S,S-acetal 1 (EWG: electron-withdrawing group), formaldehyde, and a thiol 2 in high to excellent yields. Allylic sulfoxides 4 were prepared by a highly regioselective oxidation of 3, using m-chloroperoxybenzoic acid as oxidant. Thus, starting from these readily available sulfoxides 4, 2-alkylthio-3,4-disubstituted furans 6 were efficiently constructed via the [3 + 2] annulation reaction of 4 with aldehydes 5 under mild conditions. Further replacement of the 2-alkylthio group of 6 with amines led to the formation of 2-amino-3,4-disubstituted furan derivatives 7.