98534-71-5

Basic information

• Product Name: 5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester
• Synonyms: 5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester;ethyl 5-broMo-1-phenyl-1H-pyrazole-4-carboxylate
• CAS NO: 98534-71-5
• Molecular Formula: C₁₂H₁₁BrN₂O₂
• Molecular Weight: 295.13194
• Mol File: 98534-71-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 375.053 °C at 760 mmHg
• Flash Point: 180.626 °C
• Appearance: /
• Density: 1.477 g/cm³
• CAS DataBase Reference: 5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester(98534-71-5)
• EPA Substance Registry System: 5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester(98534-71-5)

Safety Data

• Hazardous Substances Data: 98534-71-5(Hazardous Substances Data)

Usage

General Description

5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester is a chemical compound with the molecular formula C12H10BrN3O2. It is an ethyl ester derivative of 5-bromo-1-phenyl-1H-pyrazole-4-carboxylic acid, and its structure consists of a pyrazole ring with a bromine atom and a phenyl group attached. This chemical compound is commonly used in organic synthesis and pharmaceutical research as a building block for the preparation of various biologically active compounds. It is known for its potential in the development of new drugs and has demonstrated diverse pharmacological properties, making it a valuable tool for drug discovery and medicinal chemistry research.

Upstream product

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Downstream Products

• 54367-65-6 5-bromo-1-phenyl-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation

Dysregulation of the Wnt/β-catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Although numerous Wnt inhibitors have been developed, they commonly suffer from toxicity and unintended effects. Moreover, concerns have been raised in targeting this pathway because of its critical roles in maintaining stem cells and regenerating tissues and organs. On the basis of the anthelmintic drug pyrvinium and previous lead FX1128, we have developed a compound YW2065 (1c) which demonstrated excellent anti-CRC effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity. The anti-CRC effect of YW2065 was highlighted by its promising efficacy in a mice xenograft model.

Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides

1,5-Disubstituted-1H-pyrazole-4-carboxamide derivatives, useful as herbicides and aquatic algicides.