98534-76-0

Basic information

• Product Name: ETHYL 5-CHLORO-1-PHENYL PYRAZOLE-4-CARBOXYLATE
• Synonyms: ETHYL 5-CHLORO-1-PHENYL PYRAZOLE-4-CARBOXYLATE;5-Chloro-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester;ethyl 5-chloro-1-phenyl-1H-pyrazole-4-carboxylate
• CAS NO: 98534-76-0
• Molecular Formula: C₁₂H₁₁ClN₂O₂
• Molecular Weight: 250.68
• Mol File: 98534-76-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 362.486 °C at 760 mmHg
• Flash Point: 173.026 °C
• Appearance: /
• Density: 1.276 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: ETHYL 5-CHLORO-1-PHENYL PYRAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-CHLORO-1-PHENYL PYRAZOLE-4-CARBOXYLATE(98534-76-0)
• EPA Substance Registry System: ETHYL 5-CHLORO-1-PHENYL PYRAZOLE-4-CARBOXYLATE(98534-76-0)

Safety Data

• Hazardous Substances Data: 98534-76-0(Hazardous Substances Data)

Usage

General Description

ETHYL 5-CHLORO-1-PHENYL PYRAZOLE-4-CARBOXYLATE is a chemical compound with the molecular formula C13H10ClN3O2. It is an ester derivative of pyrazolecarboxylic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is a white to light brown powder that is sparingly soluble in water but soluble in organic solvents. It is known for its insecticidal and herbicidal properties and is used in the development of various pesticides and fungicides. Additionally, it has been studied for its potential antifungal and antibacterial activities, making it a versatile compound with a wide range of applications in the chemical industry.

InChI:InChI=1/C12H11ClN2O2/c1-2-17-12(16)10-8-14-15(11(10)13)9-6-4-3-5-7-9/h3-8H,2H2,1H3

Upstream product

• 89193-23-7 2-[1-dimethylaminomethylidene]-3-oxo-pentanoic acid ethyl ester 
• 100-63-0 phenylhydrazine 
• 4949-44-4 ethyl propanoylacetate 
• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 
• 64-17-5 ethanol 
• 54367-64-5 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid 

Downstream Products

• 98476-09-6 5-cyano-1-phenyl-1H-pyrazole-4-carboxylic acid,ethyl ester 
• 54367-64-5 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 98533-21-2 5-chloro-1-phenyl-N-methyl-1H-pyrazole-4-carboxamide 
• 98477-03-3 5-cyano-1-phenyl-N-methyl-1H-pyrazole-4-carboxamide 
• 117766-90-2 1-phenylpyrrolo<3,4-c>pyrazole-4,6(1H,5H)-dione 
• 117766-99-1 (5-cyano-1-phenyl-1H-pyrazole-4-yl)carbamic acid, 1,1-dimethylethyl ester 
• 117766-97-9 5-cyano-1-phenyl-1H-pyrazole-4-carbonyl azide 
• 117766-95-7 4-cyano-N-methyl-1-phenyl-1H-pyrazole-5-carboxamide 
• 117766-94-6 4-cyano-1-phenyl-1H-pyrazole-5-carboxylic acid, methyl ester 
• 117766-91-3 4-(aminocarbonyl)-1-phenyl-1H-pyrazole-5-carboxylic acid 
• 103053-10-7 5-(aminocarbonyl)-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 117766-93-5 4-cyano-1-phenyl-1H-pyrazole-5-carboxylic acid 
• 117766-92-4 4-Cyano-2-phenyl-2H-pyrazole-3-carbonyl chloride 
• 117766-98-0 5-Cyano-1-phenyl-1H-pyrazole-4-carbonyl chloride 

Relevant articles and documents

Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation

Dysregulation of the Wnt/β-catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Although numerous Wnt inhibitors have been developed, they commonly suffer from toxicity and unintended effects. Moreover, concerns have been raised in targeting this pathway because of its critical roles in maintaining stem cells and regenerating tissues and organs. On the basis of the anthelmintic drug pyrvinium and previous lead FX1128, we have developed a compound YW2065 (1c) which demonstrated excellent anti-CRC effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity. The anti-CRC effect of YW2065 was highlighted by its promising efficacy in a mice xenograft model.

Inhibitors of 11B-Hyrdoxysteroid Dehydrogenase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful