98581-93-2

Basic information

• Product Name: 3-(2,4-DICHLORO-PHENYL)-PROPIONALDEHYDE
• Synonyms: 3-(2,4-DICHLORO-PHENYL)-PROPIONALDEHYDE;2,4-Dichlorobenzenepropanal;Benzenepropanal, 2,4-dichloro-
• CAS NO: 98581-93-2
• Molecular Formula: C₉H₈Cl₂O
• Molecular Weight: 203.07
• Product Categories: Aromatics
• Mol File: 98581-93-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 271.025°C at 760 mmHg
• Flash Point: 112.384°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 3-(2,4-DICHLORO-PHENYL)-PROPIONALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-DICHLORO-PHENYL)-PROPIONALDEHYDE(98581-93-2)
• EPA Substance Registry System: 3-(2,4-DICHLORO-PHENYL)-PROPIONALDEHYDE(98581-93-2)

Safety Data

• Hazardous Substances Data: 98581-93-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8Cl2O/c10-8-4-3-7(2-1-5-12)9(11)6-8/h3-6H,1-2H2

Upstream product

• 29898-32-6 2,4-dichloro-1-iodo-benzene 
• 107-18-6 allyl alcohol 
• 146882-07-7 3-(2,4-dichlorophenyl)propan-1-ol 
• 69793-07-3 ethyl 3-(2,4-dichlorophenyl)propanoate 
• 20595-45-3 2,4-dichlorocinnamic acid 

Downstream Products

• 70017-27-5 3-(2,4-Dichlorophenyl)propenal 
• 1394046-58-2 (R)-2-(2,4-dichlorobenzyl)-5-oxohexanal 
• 848081-12-9 2-amino-5-(2',4'-dichlorobenzyl)thiophene-3-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of optically active 4-substituted 2-cyclohexenones

Recently, Nicolaou and Baran independently synthesized optically active 4-substituted 2-cyclohexenones via an efficient LiOH-mediated intramolecular aldol condensation. Thus far, application of their cyclization approach has been limited to ketoaldehydes where the R-group is branched. It is demonstrated that the LiOH-mediated cyclization, when applied to substrates containing unbranched R-groups, results in significant erosion of optical purity. A mechanistic justification is provided, and a set of neutral, organocatalyzed conditions is identified that enables cyclization with little loss in optical purity.

5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES

The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I),wherein X represents CH2 or O; R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl; R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen; R4 represents (C1-4)alkyl; R5 represents hydrogen or (C1-4)alkyl; and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.

7-PHENYL-ISOQUINOLINE-5-SULFONYLAMINO DERIVATIVES AS INHIBITORS OF AKT (PROTEINKINASE B)

The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.