98583-84-7Relevant articles and documents
Aspergillus niger catalyzes the synthesis of flavonoids from chalcones
Alarcon, Julio,Alderete, Joel,Escobar, Carlos,Araya, Ramiro,Cespedes, Carlos L.
, p. 160 - 167 (2013)
Flavonoids, which have many biological activities and have been widely used in nature, can be artificially synthesized. However, regioselective cyclization of chalcones is difficult by chemical methods. In this study, we demonstrated that Aspergillus nige
Synthesis and kinetic investigations for the isomerization process of 2–hydroxy chalcone derivatives
Shareef, Omar A.,Said, Said A.,Abdulrazaq, Ali Y.
, p. 1046 - 1054 (2020/01/09)
The wide biological activities of flavanones are mainly depends on their physical and chemical properties, thus a number of substituted 2-Hydroxy chalcones have been synthesized, and their isomerization to their corresponding flavanones was studied. In order to determine the rate constant, kinetic experiments were performed using HPLC technique in (9:1) (CH3CN:H2O) medium at different temperature (298-318) K. The obtained results were interpreted by four steps mechanism, which considered the existence of phenoxide ion as the key intermediate. This study performed with a pseudo first order (reaction in which the rate for the studied compounds follow the sequence 5 > 2 > 1 > 4 > 3, the activation energy have the same sequence for these compounds .The effect of substituents on the rate showed that electronic and steric factors play reasonable role on the stability of the product .
Photochemical Cyclization of 2'-Hydroxychalcones
Matsushima, Ryoka,Kageyama, Hiroyuki
, p. 743 - 748 (2007/10/02)
A series of 4-substituted 2'-hydroxychalcones underwent photocyclization to give the corresponding flavones selectively, but in low quantum yields, on visible irradiation in polar aprotic solvents.Hydroxylic solvents, which disturbed the formation of a cyclic intramolecular hydrogen bond, strongly retarded the photoreaction, while neither triplet quenchers nor free radical inhibitors affected the reaction.The quantum yields were independent of the light intensity, implying a one-photon process, but strongly depended on the wavelength of irradiation.Mechanisms were proposed assuming ?, ?* excited states and Weller's postulate of a dynamic equilibrium in a proton-transfer double-minimum potential.