98684-22-1Relevant articles and documents
RENIN INHIBITORS
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, (2008/06/13)
Renin inhibiting compounds of the formula: STR1 containing two . alpha.-amino acids or a single α-amino acid wherein R 1 is a phosphorus containing moiety, W is oxygen or NR 3 and A is a moiety selected from those of the formula: STR2 wherein Z is O, S, SO, SO. sub.2 and p is an integer from 1 to 2; and, when W is oxygen, A may also be a moiety of the formula STR3 and analogs thereof which compounds inhibit the substrate-cleaving action of renin, pharmaceutical compositions containing these compounds, processes for producing the compounds and methods of treating hypertension which employ the novel renin inhibitors.