98700-53-9

Basic information

• Product Name: 1, 5-Diphenyl-1H-pyrazole-4-carboxylic acid
• Synonyms: 1,5-Diphenyl-1H-pyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 1,5-diphenyl-;1,5-diphenylpyrazole-4-carboxylic acid
• CAS NO: 98700-53-9
• Molecular Formula: C₁₆H₁₂N₂O₂
• Molecular Weight: 264.28
• Mol File: 98700-53-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 451.4 °C at 760 mmHg
• Flash Point: 226.8 °C
• Appearance: /
• Density: 1.23 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1, 5-Diphenyl-1H-pyrazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1, 5-Diphenyl-1H-pyrazole-4-carboxylic acid(98700-53-9)
• EPA Substance Registry System: 1, 5-Diphenyl-1H-pyrazole-4-carboxylic acid(98700-53-9)

Safety Data

• Hazardous Substances Data: 98700-53-9(Hazardous Substances Data)

Usage

General Description

1,5-Diphenyl-1H-pyrazole-4-carboxylic acid is a chemical compound with the molecular formula C16H12N2O2. It is a derivative of pyrazole and carboxylic acid, and is commonly used in organic synthesis and pharmaceutical research. 1, 5-Diphenyl-1H-pyrazole-4-carboxylic acid has potential applications in the development of new drugs and agrochemicals, due to its diverse biological activity. It is also used as a building block for the synthesis of various compounds with potential pharmacological properties. Additionally, it has been studied for its potential anti-inflammatory, antimicrobial, and anticancer properties. Overall, 1,5-Diphenyl-1H-pyrazole-4-carboxylic acid is a versatile compound with a wide range of potential applications in the fields of medicine and agriculture.

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Downstream Products

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Relevant articles and documents

Synthesis and Rotational Isomerism of 1-Substituted Methyl (S)-[5-(2-Nitrophenyl)-1H-pyrazole-4-carbonyl]alaninates

Seven title compounds 12a-g and the (S)-prolinate analogue 13 were prepared in five steps from 2-nitrobenzoic acid (7). Reduction of the nitro group followed by derivatization of the so formed anilines 14 gave the N-alkyl-(15a-c), N-acyl-(16a,b and 19), and N-vinyl derivative 20. NMR spectra of (S)-alanine and (S)-proline derived compounds 12, 13, 14-16, 19, and 20 exhibited two sets of signals corresponding to pairs of conformational diastereomers. The free energy barriers of rotation, ΔG?298 = 82-86 kJ mol-1, were determined by 1H NMR for 12a, 12d, 12f, and 12g and evaluated by DFT calculations.

Synthesis and characterization of some pyrazole derivatives of 1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid

(Chemical Equation Presented) Compound of 4-(ethoxycarbonyl)-1,5-diphenyl- 1H-pyrazole-3-carboxylic acid 2 was obtained from the reaction of ethyl 4,5-dioxo-2-phenyl-4,5-dihydrofuran-3-carboxylate and 1-benzylidene-2- phenylhydrazine. A number of substitute pyrazole dicarboxylic acid derivatives (4, 5a-c, 6, 7, 8, 9a-m, 10, 11, 12, 13, 14) were synthesized from 1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid 3 which was prepared from basic hydrolysis of 2. Structures of synthesized compounds were characterized by 1H NMR, 13C NMR, Mass, FTIR, and elemental analysis.

Reaction of 2-dimethylaminomethylene-1,3-diones with dinucleophiles. VI. Synthesis of ethyl or methyl 1,5-disubstituted 1H-pyrazole-4-carboxylates

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