98815-45-3

Basic information

• Product Name: 1-chloro-2-(4-hydroxyphenyl)propan-2-ol
• CAS NO: 98815-45-3
• Molecular Weight: 186.638
• Mol File: 98815-45-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-chloro-2-(4-hydroxyphenyl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-2-(4-hydroxyphenyl)propan-2-ol(98815-45-3)
• EPA Substance Registry System: 1-chloro-2-(4-hydroxyphenyl)propan-2-ol(98815-45-3)

Safety Data

• Hazardous Substances Data: 98815-45-3(Hazardous Substances Data)

Upstream product

• 917-64-6 methyl magnesium iodide 
• 6305-04-0 p-hydroxyphenacyl chloride 

Relevant articles and documents

Reactions of 4-Substituted-2'-Halogenoacetophenones with Grignard Reagents

The initial reaction of 4-substituted 2'-halogenoacetophenones with an excess of methyl Grignard reagent is shown to be an attack at the 1'-carbonyl to form a halohydrin salt.The various reactions which then follow are substituent dependent.In the 4-hydroxy case the only product is 1-(4-hydroxyphenyl)-2-methylpropan-2-ol (13) which arises via a -aryl shift with simultaneous elimination of magnesium halide.When the substituent is 4-methoxy, a second pathway becomes important involving epoxide formation and a subsequent -hydride migration to the benzylic position, or attack of the Grignard reagent at the benzylic carbon of the epoxide.When the substituent is 4-bromo, the reaction proceeds exclusively via the epoxide and, following a -hydride shift, leads to the isomeric butanols (33) and (34).The reasons underlying such diversity of reactivity are discussed.