98855-71-1

Basic information

• Product Name: ((2R,3R,4S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate
• Synonyms: ((2R,3R,4S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate
• CAS NO: 98855-71-1
• Molecular Weight: 423.235
• Mol File: 98855-71-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: ((2R,3R,4S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ((2R,3R,4S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate(98855-71-1)
• EPA Substance Registry System: ((2R,3R,4S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate(98855-71-1)

Safety Data

• Hazardous Substances Data: 98855-71-1(Hazardous Substances Data)

Upstream product

• 14215-97-5 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose 
• 75-09-2 dichloromethane 
• 97614-43-2 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose 
• 22224-41-5 1,3,5-tri-O-benzoyl-α-D-ribofuranoside 
• 97614-41-0 2-O-<(trifluoromethyl)sulfonyl>-1,3,5-tri-O-benzoyl-α-D-ribofuranose 

Downstream Products

• 329187-80-6 ((2R,3R,4S,5R)-3-(benzoyloxy)-5-(2,6-dichloro-9H-purin-9-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate 
• 355138-50-0 6-amino-2-chloro-9-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosyl)-9H-purine 
• 1590395-68-8 1-((2R,3S,4R,5R)-4-(benzoyloxy)-5-((benzoyloxy)methyl)-3-fluorotetrahydrofuran-2-yl)-3-carbamoylpyridin-1-ium 
• 909101-46-8 4-chloro-7-(2-deoxy-3,5-di-O-benzoyl-β-D-arabinofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine 
• 1338073-06-5 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(thiophen-3-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1338073-04-3 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(furan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1338073-01-0 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1338072-98-2 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1338072-84-6 7-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine 
• 1338072-82-4 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidine 
• 1338072-79-9 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-4-(thiazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1338072-77-7 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-4-(thiophen-3-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1338072-75-5 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-4-(furan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 169516-55-6 4-chloro-7-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 

Relevant articles and documents

A Simple and Convenient Method for the Synthesis of 1-(2-Deoxy-2-fuoro-β-D-arabinofuranosyl)-5-iodocytosine

1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) is a pyrimidine nucleoside analog with activity against various herpes viruses. In this study, FIAC was conveniently synthesized by a substitution reaction between ((2R,3S,4S)-3-(benzoyloxy)-

Revealing CD38 cellular localization using a cell permeable, mechanism-based fluorescent small-molecule probe

Nicotinamide adenine dinucleotide (NAD) is increasingly recognized as an important signaling molecule that affects numerous biological pathways. Thus, enzymes that metabolize NAD can have important biological functions. One NAD-metabolizing enzyme in mammals is CD38, a type II transmembrane protein that converts NAD primarily to adenosine diphosphate ribose (ADPR) and a small amount of cyclic adenosine diphosphate ribose (cADPR). Localization of CD38 was originally thought to be only on the plasma membrane, but later reports showed either significant or solely, intracellular CD38. With the efficient NAD-hydrolysis activity, the intracellular CD38 may lead to depletion of cellular NAD, thus producing harmful effects. Therefore, the intracellular localization of CD38 needs to be carefully validated. Here, we report the synthesis and application of a cell permeable, fluorescent small molecule (SR101-F-araNMN) that can covalently label enzymatically active CD38 with minimal perturbation of live cells. Using this fluorescent probe, we revealed that CD38 is predominately on the plasma membrane of Raji and retinoic acid (RA)-treated HL-60 cells. Additionally, the probe revealed no CD38 expression in K562 cells, which was previously reported to have solely intracellular CD38. The finding that very little intracellular CD38 exists in these cell lines suggests that the major enzymatic function of CD38 is to hydrolyze extracellular rather than intracellular NAD. The fluorescent activity-based probes that we developed allow the localization of CD38 in different cells to be determined, thus enabling a better understanding of the physiological function.

Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′- fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides

A series of novel sugar-modified derivatives of cytostatic 7-hetaryl-7-deazaadenosines (2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides) was prepared and screened for biological activity. Th