98953-21-0

Basic information

• Product Name: 4-Pyridinecarboxylicacid,2-(acetylamino)-,methylester(9CI)
• Synonyms: 4-Pyridinecarboxylicacid,2-(acetylamino)-,methylester(9CI);4-Pyridinecarboxylicacid,2-(acetylamino)-, ethyl ester;4-Pyridinecarboxylic acid, 2-(acetylamino)-, methyl ester;methyl 2-(acetylamino)isonicotinate;methyl 2-acetamidoisonicotinate;Methyl 2-acetaMidopyridine-4-carboxylate
• CAS NO: 98953-21-0
• Molecular Formula: C9H10N2O3
• Molecular Weight: 194.19
• Product Categories: AMINOACID
• Mol File: 98953-21-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 403.685 °C at 760 mmHg
• Flash Point: 197.942 °C
• Appearance: /
• Density: 1.264 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Pyridinecarboxylicacid,2-(acetylamino)-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarboxylicacid,2-(acetylamino)-,methylester(9CI)(98953-21-0)
• EPA Substance Registry System: 4-Pyridinecarboxylicacid,2-(acetylamino)-,methylester(9CI)(98953-21-0)

Safety Data

• Hazardous Substances Data: 98953-21-0(Hazardous Substances Data)

Usage

General Description

4-Pyridinecarboxylicacid,2-(acetylamino)-,methylester(9CI) is a chemical compound, it's an ester derivative of pyridine carboxylic acid with an acetylamino group at the 2-carbon position on the pyridine ring. Its chemical structure features a methyl ester bonded to the carboxylic acid group for increased stability and reactivity. 4-Pyridinecarboxylicacid,2-(acetylamino)-,methylester(9CI) belongs to the class of organic compounds known as pyridinecarboxylic acids and derivatives. These are compounds containing a pyridine ring bearing a carboxylic acid group or a derivative thereof.

InChI:InChI=1/C9H10N2O3/c1-6(12)11-8-5-7(3-4-10-8)9(13)14-2/h3-5H,1-2H3,(H,10,11,12)

Upstream product

• 13362-28-2 2-aminoisonicotinic acid 
• 54221-95-3 2-(acetylamino)isonicotinic acid 
• 5327-32-2 2-acetylamino-4-methylpyridine 
• 6937-03-7 methyl 2-aminoisonicotinate 
• 108-24-7 acetic anhydride 

Downstream Products

• 14436-36-3 2-(acetylamido)isonicotinamide 
• 899452-29-0 methyl 1-(difluoromethyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 13538-42-6 2-amino-isonicotinamide 
• 1417334-91-8 C₁₆H₁₄N₄O₂S 
• 1417334-89-4 N-(4-(5-(3-methoxybenzylthio)-1,3,4-oxadiazol-2-yl)pyridin-2-yl)acetamide 
• 1417334-90-7 C₁₇H₁₃N₅O₂S 

Relevant articles and documents

Structure-based optimization of oxadiazole-based GSK-3 inhibitors

Inhibition of glycogen synthase kinase-3 (GSK-3) induces neuroprotective effects, e.g. decreases β-amyloid production and reduces tau hyperphosphorylation, which are both associated with Alzheimer's disease (AD). The two isoforms of GSK-3 in mammalians are GSK-3α and β, which share 98% homology in their catalytic domains. We investigated GSK-3 inhibitors based on 2 different scaffolds in order to elucidate the demands of the ATP-binding pocket [1]. Particularly, the oxadiazole scaffold provided potent and selective GSK-3 inhibitors. For example, the most potent inhibitor of the present series, the acetamide 26d, is characterized by an IC50 of 2 nM for GSK-3α and 17 nM for GSK-3β. In addition, the benzodioxane 8g showed up to 27-fold selectivity for GSK-3α over GSK-3β, with an IC 50 of 35 nM for GSK-3α. Two GSK-3 inhibitors were further profiled for efficacy and toxicity in the wild-type (wt) zebrafish embryo assay to evaluate simultaneously permeability and safety.

Bicyclic fibrinogen antagonists

This invention relates to compounds of the formulae: wherein A1is O, S, N—R1or CHR1; A4is N—R4or CHR4; R2is a sidechain containing an acid or ester group; R1, R4and R5are substituents such as H, alkyl and aryl alkyl, and R6is a sidechain containing a nitrogen group; and pharmaceutically acceptable salts thereof, which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.