98961-97-8

Basic information

• Product Name: PIPERAZINE-1-SULFONIC ACID DIMETHYLAMIDE
• Synonyms: IFLAB-BB F1757-0250;AKOS BBS-00005892;TIMTEC-BB SBB010189;PIPERAZINE-1-SULFONIC ACID DIMETHYLAMIDE;PIPERAZINE-1-SULPHONIC ACID DIMETHYLAMIDE;N,N-DIMETHYL-1-PIPERAZINE SULFONAMIDE;N,N-DIEMTHYL-1-PIPERAZINE SULFONAMIDE;N,N-DIMETHYLPIPERAZINE-1-SULFONAMIDE
• CAS NO: 98961-97-8
• Molecular Formula: C₆H₁₅N₃O₂S
• Molecular Weight: 193.27
• Mol File: 98961-97-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 54-56°C
• Boiling Point: 314.8vat 760 mmHg
• Flash Point: 144.2 ºC
• Appearance: /
• Density: 1.28 g/cm³
• Vapor Pressure: 0.000455mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.23±0.10(Predicted)
• CAS DataBase Reference: PIPERAZINE-1-SULFONIC ACID DIMETHYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERAZINE-1-SULFONIC ACID DIMETHYLAMIDE(98961-97-8)
• EPA Substance Registry System: PIPERAZINE-1-SULFONIC ACID DIMETHYLAMIDE(98961-97-8)

Safety Data

• Hazardous Substances Data: 98961-97-8(Hazardous Substances Data)

Usage

General Description

PIPERAZINE-1-SULFONIC ACID DIMETHYLAMIDE is a synthetic chemical compound with a molecular formula C6H14N2O3S. It is commonly used as a buffering agent in a variety of pharmaceuticals and biological applications. PIPERAZINE-1-SULFONIC ACID DIMETHYLAMIDE is known for its ability to maintain the pH of a solution at a constant level, making it valuable in the production of drugs, cosmetics, and other consumer products. PIPERAZINE-1-SULFONIC ACID DIMETHYLAMIDE is also used as a stabilizer in certain medications and as a reagent in biochemical research. Its versatile applications and stable properties make it a valuable component in many industries.

InChI:InChI=1/C6H15N3O2S/c1-8(2)12(10,11)9-5-3-7-4-6-9/h7H,3-6H2,1-2H3

Upstream product

• 110-85-0 piperazine 
• 13360-57-1 dimethylamino sulfonyl chloride 
• 253176-45-3 (S)-6'-chloro-N-((R)-hept-6-en-3-ylsulfonyl)-5-((2-((S)-1-hydroxyallyl)-2-methylcyclobutyl)methyl)-3',4,4',5-tetrahydro-2H,2’H-spiro[benzo[b][1,4]oxazepine-3,1’-naphthalene]-7-carboxamide 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 654071-76-8 4-[4-(1-benzyloxy-(R)-ethyl)-6-chloro-[1,3,5]triazin-2-yl]piperazine-1-sulfonic acid dimethylamide 
• 99191-22-7 N,N-dimethyl-4-(pyrimidin-2-yl)piperazine-1-sulfonamide 
• 1610518-53-0 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-N,N-dimethylpiperazine-1-sulphonamide 
• 1445902-12-4 4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide 
• 1445902-10-2 4-{4-[(S)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide 
• 1280479-82-4 C₂₅H₃₁Cl₂FN₄O₃S 
• 1226860-41-8 6-methylbenzo[b]thiophene-2-carboxylic acid {1-[(S)-1-benzyl-4-(4-dimethylsulfamoylpiperazin-1-yl)butylcarbamoyl]cyclopentyl}amide 
• 1190058-16-2 N-(7-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide 

Relevant articles and documents

Synthesis and evaluation of 4-(2-hydroxypropyl)piperazin-1-yl) derivatives as Hsp90 inhibitors

We previously reported 4-(3-((6-bromonaphthalen-2-yl)oxy)-2-hydroxypropyl)-N,N-dimethylpiperazine-1-sulfonamide (1) as a novel heat shock protein 90 inhibitor with moderate activity. In our ongoing efforts for the discovery of Hsp90 modulators we undertake structural investigations on 1. Series of the titled compound were designed, synthesized and evaluated. We have found that compounds with a hydroxyl group at C-4 of the aryl ring on the piperazine moiety possess Hsp90 inhibition properties. Compound 6f with improved activity could be further developed and optimized as Hsp90 inhibitor.

Multifunctional Compounds and Methods of Use Thereof

Compositions comprising multifunctional agents and methods of use thereof are provided.

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.