99010-49-8Relevant articles and documents
Synthesis and structure - Activity-relationships of 1H-imidazo[4,5-c] quinolines that induce interferon production
Gerster, John F.,Lindstrom, Kyle J.,Miller, Richard L.,Tomai, Mark A.,Birmachu, Woubalem,Bomersine, Shannon N.,Gibson, Shiela J.,Imbertson, Linda M.,Jacobson, Joel R.,Knafla, Roy T.,Maye, Peter V.,Nikolaides, Nickolas,Oneyemi, Folakemi Y.,Parkhurst, Gwen J.,Pecore, Sharon E.,Reiter, Michael J.,Scribner, Lisa S.,Testerman, Tracy L.,Thompson, Natalie J.,Wagner, Tammy L.,Weeks, Charles E.,Andre, Jean-Denis,Lagain, Daniel,Bastard, Yvon,Lupu, Michel
, p. 3481 - 3491 (2007/10/03)
1H-Imidazo-[4,5-c]quinolines were prepared while investigating novel nucleoside analogues as potential antiviral agents. While these compounds showed no direct antiviral activity when tested in a number of cell culture systems, some demonstrated potent inhibition of virus lesion development in an intravaginal guinea pig herpes simplex virus-2 assay. We have determined that the in vivo antiviral activity can be attributed to the ability of these molecules to induce the production of cytokines, especially interferon (IFN), in this model. Subsequently, we found that the compounds also induce in vitro production of IFN in human peripheral blood mononuclear cells (hPBMCs). The in vitro results reported herein and the in vivo results reported previously led to the discovery of imiquimod, 26, which was developed as a topical agent and has been approved for the treatment of genital warts, actinic keratosis, and superficial basal cell carcinoma.
New Bronchodilators. 1. 1,5-Substituted 1H-Imidazoquinolin-4(5H)ones
Suzuki, Fumio,Kuroda, Takeshi,Nakasato, Yoshisuke,Manabe, Haruhiko,Ohmori, Kenji,et al.
, p. 4045 - 4053 (2007/10/02)
A series of novel xanthine-based tricyclic heterocycles in 1H-imidazoquinolin-4(5H)-ones was designed, synthesized, and tested as potential active bronchodilators.Inhibition of the Schulz-Dale (SD) reaction-induced contraction in trachea and inhibi