99044-54-9

Basic information

• Product Name: 7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine
• Synonyms: 7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine;4-chloro-7-benzyl-7H-Pyrrolo[2,3-d]pyrimidin-2-amine
• CAS NO: 99044-54-9
• Molecular Formula: C₁₃H₁₁ClN₄
• Molecular Weight: 258.70624
• Mol File: 99044-54-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine(99044-54-9)
• EPA Substance Registry System: 7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine(99044-54-9)

Safety Data

• Hazardous Substances Data: 99044-54-9(Hazardous Substances Data)

Upstream product

• 7355-55-7 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 
• 97570-31-5 (2-amino-4,6-dichloropyrimidin-5-yl)acetaldehyde 
• 97570-30-4 5-allyl-4,6-dichloro-2-aminopyrimidine 
• 97570-29-1 5-allyl-2-amino-4,6-dihydroxypyrimidine 
• 97570-32-6 2-(2-amino-4,6-dichloropyrimidin-5-yl) acetaldehyde diethyl acetal 
• 2049-80-1 (2-propenyl)propanedioic acid diethyl ester 
• 100-39-0 benzyl bromide 
• 84955-31-7 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 99044-52-7 N⁴-Benzyl-6-chloro-5-(2,2-diethoxy-ethyl)-pyrimidine-2,4-diamine 

Downstream Products

• 914496-82-5 4-(7-benzyl-2-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)-3,5-dimethyl-benzonitrile 
• 914496-86-9 4-[7-benzyl-4-(2,4,6-trimethyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-benzonitrile 
• 914496-20-1 4-[4-(2,4,6-trimethyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-benzonitrile 
• 914496-85-8 (7-benzyl-2-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(2,4,6-trimethyl-phenyl)-amine 
• 914496-76-7 7-benzyl-2-fluoro-4-(2,4,6-trimethyl-phenoxy)-7H-pyrrolo[2,3-d]pyrimidine 
• 914496-79-0 7-benzyl-2-fluoro-4-(2,4,6-trimethyl-phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 914496-81-4 4-(2-amino-7-benzyl-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)-3,5-dimethyl-benzonitrile 
• 914496-75-6 7-benzyl-4-(2,4,6-trimethyl-phenoxy)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine 
• 914496-84-7 7-benzyl-N₄-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine 
• 181480-51-3 2-Amino-7-benzyl-3-methyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 96080-37-4 2-amino-7-benzylpyrrolo<2,3-d>pyrimidin-4-one 

Relevant articles and documents

An improved synthesis approach of the HIV-1 inhibitor RDEA427, a pyrrolo[2,3-d]pyrimidine derivative

The diarylpyrimidine-like derivative RDEA427 is a highly potent inhibitor against wild-type and a wide range of drug-resistant HIV-1 strains and has attracted much attention. However, the yield of its reported synthesis is too low and the route is less environment-friendly and uneconomic. In order to achieve a short and more economic synthesis of RDEA427, an investigation was carried out. The optimized synthesis approach of RDEA427 was accomplished in an increased overall yield (39%). Moreover, the new route is more environment-friendly and economic. This work will accelerate the drug discovery process.

The synthesis and determination of acidic ionization constants of certain 5-substituted 2-aminopyrrolo[2,3-d]pyrimidin-4-ones and methylated analogs

The acidic ionization constants were determined for a series of 5-substituted 2-aminopyrrolo[2,3-dl-pyrimidin-4-ones and N-3- and N-7-methylated analogs thereof. The syntheses of the methylated analogs are also described.