99088-57-0

Basic information

• Product Name: 1-methyl-3-(o-tolyl)quinazoline-2,4(1H,3H)-dione
• Synonyms: 1-methyl-3-(o-tolyl)quinazoline-2,4(1H,3H)-dione
• CAS NO: 99088-57-0
• Molecular Weight: 266.299
• Mol File: 99088-57-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-methyl-3-(o-tolyl)quinazoline-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-3-(o-tolyl)quinazoline-2,4(1H,3H)-dione(99088-57-0)
• EPA Substance Registry System: 1-methyl-3-(o-tolyl)quinazoline-2,4(1H,3H)-dione(99088-57-0)

Safety Data

• Hazardous Substances Data: 99088-57-0(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 119-68-6 N-Methylanthranilic acid 
• 95-53-4 o-toluidine 
• 10328-92-4 N-Methylisatoic anhydride 
• 614-68-6 2-tolyl isocyanate 
• 2385-41-3 methaqualone-1-oxide 
• 104700-29-0 1a-Methyl-2-o-tolyl-1a,2-dihydro-1-oxa-2,7b-diaza-cyclopropa[a]naphthalen-3-one 

Relevant articles and documents

Pd(ii)-Catalyzed [4 + 1 + 1] cycloaddition of simple: O -aminobenzoic acids, CO and amines: Direct and versatile synthesis of diverse N -substituted quinazoline-2,4(1 H,3 H)-diones

The mild, efficient, and straightforward synthesis of pharmaceutically and biologically active N3-substituted and N1,N3-disubstituted quinazoline-2,4-(1H,3H)-diones from simple and readily available substrates has been a huge challenge. Described here is a Pd(ii)-catalyzed [4 + 1 + 1] modular synthesis of diverse quinazoline-2,4-(1H,3H)-diones through one-pot cascade reactions of cyclocondensation of o-(alkyl)aminobenzoic acids with CO, amidation of the intermediate isatoic anhydrides with amines, and unprecedented carbonylation of the resulting o-aminobenzamides with CO under 1 atm and 60 °C conditions. The chemoselective and versatile multicomponent reaction allows for the diversities of the products including N3-substituted and N1,N3-disubstituted products, and even makes the substituents on N1,N3 the same or different from each other, which cannot be achieved by most traditional synthetic strategies. This journal is

Ni(COD)(DQ): An Air-Stable 18-Electron Nickel(0)–Olefin Precatalyst

We report that Ni(COD)(DQ) (COD=1,5-cyclooctadiene, DQ=duroquinone), an air-stable 18-electron complex originally described by Schrauzer in 1962, is a competent precatalyst for a variety of nickel-catalyzed synthetic methods from the literature. Due to its apparent stability, use of Ni(COD)(DQ) as a precatalyst allows reactions to be conveniently performed without use of an inert-atmosphere glovebox, as demonstrated across several case studies.

Proof of an intermediate oxaziridine during the photochemical reaction of methaqualone-1-oxide

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